ArticleeLife2016
Inhibition in the auditory brainstem enhances signal representation and regulates gain in complex acoustic environments.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Neuronal processing of complex sounds in the prothoracic ganglion of a bushcricket.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Article
- Synaptic input variation enhances rate coding at the expense of temporal precision in cochlear nucleus neurons.PLoS biology · 2026Article
- Age-related auditory nerve deficits propagate central gain throughout the auditory system: Associations with cortical microstructure and speech recognition.Neurobiology of aging · 2026Article
- Cellular and synaptic specializations for sub-millisecond precision in the mammalian auditory brainstem.Frontiers in cellular neuroscience · 2025Review
- Distinguishing the activity of adjacent somatosensory nuclei within the brainstem using 3T fMRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Electrophysiological correlates of divergent projections in the avian superior olivary nucleus.Journal of neurophysiology · 2024Article
- Lineage-tracing reveals an expanded population of NPY neurons in the inferior colliculus.Journal of neurophysiology · 2024Article
- Lineage-tracing reveals an expanded population of NPY neurons in the inferior colliculus.bioRxiv : the preprint server for biology · 2024Article
- Article
- Presynaptic Rac1 controls synaptic strength through the regulation of synaptic vesicle priming.eLife · 2022Article
- Article
- Auditory Brainstem Models: Adapting Cochlear Nuclei Improve Spatial Encoding by the Medial Superior Olive in Reverberation.Journal of the Association for Research in Otolaryngology : JARO · 2021Article
- Theoretical Relationship Between Two Measures of Spike Synchrony: Correlation Index and Vector Strength.Frontiers in neuroscience · 2021Article
- Purinergic Modulation of Activity in the Developing Auditory Pathway.Neuroscience bulletin · 2020Review
- Modeling the Short-Term Dynamics ofThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Spectral tuning of adaptation supports coding of sensory context in auditory cortex.PLoS computational biology · 2019Article
- Principal Neurons in the Anteroventral Cochlear Nucleus Express Cell-Type Specific Glycine Receptor α Subunits.Neuroscience · 2019Article
- A temporal integration mechanism enhances frequency selectivity of broadband inputs to inferior colliculus.PLoS biology · 2019Article
- Age-related Changes in Neural Coding of Envelope Cues: Peripheral Declines and Central Compensation.Neuroscience · 2019Review
- Functional Development of Principal Neurons in the Anteroventral Cochlear Nucleus Extends Beyond Hearing Onset.Frontiers in cellular neuroscience · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inhibition plays a crucial role in neural signal processing, shaping and limiting responses. In the auditory system, inhibition already modulates second order neurons in the cochlear nucleus, e.g. spherical bushy cells (SBCs). While the physiological basis of inhibition and excitation is well described, their functional interaction in signal processing remains elusive. Using a combination of in vivo loose-patch recordings, iontophoretic drug application, and detailed signal analysis in the Mongolian Gerbil, we demonstrate that inhibition is widely co-tuned with excitation, and leads only to minor sharpening of the spectral response properties. Combinations of complex stimuli and neuronal input-output analysis based on spectrotemporal receptive fields revealed inhibition to render the neuronal output temporally sparser and more reproducible than the input. Overall, inhibition plays a central role in improving the temporal response fidelity of SBCs across a wide range of input intensities and thereby provides the basis for high-fidelity signal processing.
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