Evidence map›Paper›PMID 27855706›Full record

ArticleJournal of neuroinflammation2016

Human class I major histocompatibility complex alleles determine central nervous system injury versus repair.

Bharath Wootla, Aleksandar Denic, Jens O Watzlawik, Arthur E Warrington, Laurie J Zoecklein, Louisa M Papke-Norton, Chella David, Moses Rodriguez

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroinflammation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Bharath WootlaDepartment of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Aleksandar DenicDepartment of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Jens O WatzlawikDepartment of Neuroscience, Mayo Clinic, 4500 San Pablo Road S, Jacksonville, FL, 32224, USA.
Arthur E WarringtonDepartment of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Laurie J ZoeckleinDepartment of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Louisa M Papke-NortonDepartment of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Chella DavidDepartment of Immunology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Moses RodriguezDepartment of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. Rodriguez.Moses@mayo.edu.ORCID 0000-0001-6328-6497
Mayo Clinic · USMayo Clinic in Florida · US

Funding

Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
NCATS NIH HHS UL1 TR000135
6 · The paper itself

Abstract

backgroundWe investigated the role of human HLA class I molecules in persistent central nervous system (CNS) injury versus repair following virus infection of the CNS.

methodsHuman class I A11

resultsFollowing infection with TMEV, a picornavirus, the Aβ

conclusionsThe findings support the hypothesis that the expression of a single human class I MHC molecule, independent of persistent virus infection, influences the extent of sub frequent chronic neuronal injury or repair in the absence of a class II MHC immune response.

Indexed as

Analysis of VarianceAnimalsAntibodiesCardiovirus InfectionsCentral Nervous SystemDisease Models, AnimalFlow CytometryHistocompatibility Antigens Class IHLA-A11 AntigenHLA-B27 AntigenHumansMiceMice, Inbred C57BLMice, TransgenicRNA, MessengerTheilovirusAntibodiesHistocompatibility Antigens Class IHLA-A11 AntigenHLA-B27 AntigenRNA, MessengerViral ProteinsHuman leukocyte antigenMajor histocompatibility complexPicornavirusTheiler’s murine encephalomyelitis virusVirus persistence

Identifiers

PMID27855706
PMCPMC5112886
OpenAlexW2553293674

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.