Evidence map›Paper›PMID 27855695›Full record

ArticleJournal of hematology & oncology2016

Microarray-based analysis and clinical validation identify ubiquitin-conjugating enzyme E2E1 (UBE2E1) as a prognostic factor in acute myeloid leukemia.

Hongmei Luo, Yu Qin, Frederic Reu, Sujuan Ye, Yang Dai, Jingcao Huang, Fangfang Wang, Dan Zhang, Ling Pan, Huanling Zhu and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of hematology & oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Hongmei LuoDepartment of Hematology, Hematology Research Laboratory, West China Hospital, Sichuan University, #37 GuoXue Xiang Street, Chengdu, 610041, China.
Yu QinDepartment of Internal Medicine, Weiss Memorial Hospital, University of Illinois, Chicago, IL, USA.
Frederic ReuDepartment of Haemotologic Oncology, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH, USA.
Sujuan YeSinopec Southwest Company, Chengdu, China.
Yang DaiDepartment of Hematology, Hematology Research Laboratory, West China Hospital, Sichuan University, #37 GuoXue Xiang Street, Chengdu, 610041, China.
Jingcao HuangDepartment of Hematology, Hematology Research Laboratory, West China Hospital, Sichuan University, #37 GuoXue Xiang Street, Chengdu, 610041, China.
Fangfang WangDepartment of Hematology, Hematology Research Laboratory, West China Hospital, Sichuan University, #37 GuoXue Xiang Street, Chengdu, 610041, China.
Dan ZhangDepartment of Hematology, Hematology Research Laboratory, West China Hospital, Sichuan University, #37 GuoXue Xiang Street, Chengdu, 610041, China.
Ling PanDepartment of Hematology, Hematology Research Laboratory, West China Hospital, Sichuan University, #37 GuoXue Xiang Street, Chengdu, 610041, China.
Huanling ZhuDepartment of Hematology, Hematology Research Laboratory, West China Hospital, Sichuan University, #37 GuoXue Xiang Street, Chengdu, 610041, China.
Yu WuDepartment of Hematology, Hematology Research Laboratory, West China Hospital, Sichuan University, #37 GuoXue Xiang Street, Chengdu, 610041, China.
Ting NiuDepartment of Hematology, Hematology Research Laboratory, West China Hospital, Sichuan University, #37 GuoXue Xiang Street, Chengdu, 610041, China.
Zhijian XiaoChinese Academy of Medical Sciences, Institute of Hematology and Blood Diseases Hospital, Tianjin, China.
Yuhuan ZhengDepartment of Hematology, Hematology Research Laboratory, West China Hospital, Sichuan University, #37 GuoXue Xiang Street, Chengdu, 610041, China. yuhuan_zheng@163.com.
Ting LiuDepartment of Hematology, Hematology Research Laboratory, West China Hospital, Sichuan University, #37 GuoXue Xiang Street, Chengdu, 610041, China. liuting@scu.edu.cn.
West China Hospital of Sichuan University · CNSichuan University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevious research suggested that single gene expression might be correlated with acute myeloid leukemia (AML) survival. Therefore, we conducted a systematical analysis for AML prognostic gene expressions.

methodsWe performed a microarray-based analysis for correlations between gene expression and adult AML overall survival (OS) using datasets GSE12417 and GSE8970. Positive findings were validated in an independent cohort of 50 newly diagnosed, non-acute promyelocytic leukemia (APL) AML patients by quantitative RT-PCR and survival analysis.

resultsMicroarray-based analysis suggested that expression of eight genes was each associated with 1-year and 3-year AML OS in both GSE12417 and GSE8970 datasets (p < 0.05). Next, we validated our findings in an independent cohort of AML samples collected in our hospital. We found that ubiquitin-conjugating enzyme E2E1 (UBE2E1) expression was adversely correlated with AML survival (p = 0.04). Multivariable analysis showed that UBE2E1

conclusionsIn summary, we demonstrated that UBE2E1 expression was a novel prognostic factor in adult, non-APL AML patients.

Indexed as

AdultDisease-Free SurvivalFemaleGene Expression ProfilingHumansInduction ChemotherapyLeukemia, Myeloid, AcuteLeukemia, Promyelocytic, AcuteMaleMicroarray AnalysisPrognosisSurvival AnalysisUbiquitin-Conjugating EnzymesUBE2E1 protein, humanUbiquitin-Conjugating EnzymesAcute myeloid leukemiaPrognosisUBE2E1

Identifiers

PMID27855695
PMCPMC5114814
OpenAlexW2550200230

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.