ArticleRespiratory research2016
Diagnostic accuracy of methacholine challenge tests assessing airway hyperreactivity in asthmatic patients - a multifunctional approach.
Article in Respiratory research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
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- Microbial Volatile Organic Compounds (MVOCs) - rare cause of occupational asthma in two veterinarians.Respiratory medicine case reports · 2026Article
- Innovative machine learning-based prediction of early airway hyperresponsiveness using baseline pulmonary function parameters.Frontiers in medicine · 2025Article
- The Value of Body Plethysmography (sGaw) in the Assessment of Airway Hyperreactivity in Cough Variant Asthma.Journal of clinical medicine · 2024Article
- Single and multiple breath nitrogen washout compared with the methacholine test in patients with suspected asthma and normal spirometry.BMJ open respiratory research · 2024Observational
- Predicting parameters of airway dynamics generated from inspiratory and expiratory plethysmographic airway loops, differentiating subtypes of chronic obstructive diseases.BMJ open respiratory research · 2024Article
- Assessment of functional diversities in patients with Asthma, COPD, Asthma-COPD overlap, and Cystic Fibrosis (CF).PloS one · 2024Article
- Measuring short-term changes in specific ventilation using dynamic specific ventilation imaging.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Functional Predictors Discriminating Asthma-COPD Overlap (ACO) from Chronic Obstructive Pulmonary Disease (COPD).International journal of chronic obstructive pulmonary disease · 2022Article
- Normative reference equations of airway dynamics assessed by whole-body plethysmography during spontaneous breathing evaluated in infants, children, and adults.Physiological reports · 2021Article
- Regional airflow obstruction after bronchoconstriction and subsequent bronchodilation in subjects without pulmonary disease.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Bronchodilator Response in Patients with COPD, Asthma-COPD-Overlap (ACO) and Asthma, Evaluated by Plethysmographic and Spirometric z-Score Target Parameters.International journal of chronic obstructive pulmonary diseaseArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere are few studies comparing diagnostic accuracy of different lung function parameters evaluating dose-response characteristics of methacholine (MCH) challenge tests (MCT) as quantitative outcome of airway hyperreactivity (AHR) in asthmatic patients. The aim of this retrospectively analysis of our database (Clinic Barmelweid, Switzerland) was, to assess diagnostic accuracy of several lung function parameters quantitating AHR by dose-response characteristics.
methodsChanges in effective specific airway conductance (sG
resultsIn the assessment of AHR, whole-body plethysmography offers in addition to spirometry indices of airways conductance and thoracic lung volumes, which are incorporated in the parameter sG
conclusionsApplying plethysmographic tidal breathing analysis in addition to spirometry in MCTs provides relevant advantages. The absence of deep and maximal inhalations and forced expiratory manoeuvres improve the subject's cooperation and coordination, and provide sensitive and differentiated test results, improving diagnostic accuracy. Moreover, by the combined assessment, pulmonary hyperinflation and dysanapsis can be respected in the differentiation between "asthmatics" and "non-asthmatics".
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