ArticleThe Clinical neuropsychologist2017
Traumatic brain injury history is associated with earlier age of onset of Alzheimer disease.
Article in The Clinical neuropsychologist, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.
- Is dementia more likely following traumatic brain injury? A systematic review.Journal of neurology · 2023Pooled it
- Reducing burden and anxiety for caregivers of veterans with traumatic brain injury and dementia: Randomized controlled trial of the resources for enhancing all caregivers' health-Hope intervention.Rehabilitation psychology · 2026Trial
- Traumatic brain injury and late-life Alzheimer's disease neuropathology: Quantitative investigation in the Adult Changes in Thought study.Journal of Alzheimer's disease : JAD · 2026Article
- Neurodegenerative Diseases in Male Former First-Class New Zealand Rugby Players.Sports medicine (Auckland, N.Z.) · 2026Article
- PolyGR-containing aggregates link with pathology and clinical features of Alzheimer's disease.Acta neuropathologica · 2025Article
- Traumatic brain injury, changes in plasma amyloid, tau, and neurodegenerative biomarkers, and dementia risk.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Dementia Risk Due to Traumatic Brain Injury in Subtypes of Dementia in the Welsh Population.Neurology · 2025Observational
- Prevalence of low scores in the Uniform Data Set version 3.0: Comparison of older adults with and without a self-reported history of traumatic brain injury.Journal of the International Neuropsychological Society : JINS · 2025Article
- A preliminary study on plasma markers across cognitive stages and links to a history of mild traumatic brain injury.Journal of Alzheimer's disease : JAD · 2025Article
- Demographics, Clinical Characteristics, and Well-Being of Veterans with TBI and Dementia and Their Caregivers.Geriatrics (Basel, Switzerland) · 2024Article
- History of traumatic brain injury is associated with increased grey-matter loss in patients with mild cognitive impairment.Journal of neurology · 2024Article
- 2024 Alzheimer's disease facts and figures.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Associations between concussion and more severe TBIs, mild cognitive impairment, and early-onset dementia among military retirees over 40 years.Frontiers in neurology · 2024Article
- Association Between Traumatic Brain Injury and Cognitive Decline Among Middle-to-Older Aged Men in the Vietnam Era Twin Study of Aging.Neurotrauma reports · 2024Article
- History of traumatic brain injury does not alter course of neurocognitive decline in older adults with and without cognitive impairment.Neuropsychology · 2023Article
- Inflammaging, cellular senescence, and cognitive aging after traumatic brain injury.Neurobiology of disease · 2023Review
- The Labyrinthine Landscape of APP Processing: State of the Art and Possible Novel Soluble APP-Related Molecular Players in Traumatic Brain Injury and Neurodegeneration.International journal of molecular sciences · 2023Article
- Association of Traumatic Brain Injury with Late Life Neuropathological Outcomes in a Community-Based Cohort.Journal of Alzheimer's disease : JAD · 2023Article
- How Traumatic Brain Injury History Relates to Brain Health MRI Markers and Dementia Risk: Findings from the 3C Dijon Cohort.Journal of Alzheimer's disease : JAD · 2023Article
- Inhibition of Caspase 3 and Caspase 9 Mediated Apoptosis: A Multimodal Therapeutic Target in Traumatic Brain Injury.Current neuropharmacology · 2023Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveThis study examined whether a history of traumatic brain injury (TBI) is associated with earlier onset of Alzheimer disease (AD), independent of apolipoprotein ε4 status (Apoe4) and gender.
methodParticipants with a clinical diagnosis of AD (n = 7625) were obtained from the National Alzheimer's Coordinating Center Uniform Data Set, and categorized based on self-reported lifetime TBI with loss of consciousness (LOC) (TBI+ vs. TBI-) and presence of Apoe4. ANCOVAs, controlling for gender, race, and education were used to examine the association between history of TBI, presence of Apoe4, and an interaction of both risk factors on estimated age of AD onset.
resultsEstimated AD onset differed by TBI history and Apoe4 independently (p's < .001). The TBI+ group had a mean age of onset 2.5 years earlier than the TBI- group. Likewise, Apoe4 carriers had a mean age of onset 2.3 years earlier than non-carriers. While the interaction was non-significant (p = .34), participants having both a history of TBI and Apoe4 had the earliest mean age of onset compared to those with a TBI history or Apoe4 alone (M
conclusionsHistory of self-reported TBI can be associated with an earlier onset of AD-related cognitive decline, regardless of Apoe4 status and gender. TBI may be related to an underlying neurodegenerative process in AD, but the implications of age at time of injury, severity, and repetitive injuries remain unclear.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.