ArticleBritish journal of cancer2017
In utero exposure to radiation and haematological malignancies: pooled analysis of Southern Urals cohorts.
Article in British journal of cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed.
- A Historical Survey of Key Epidemiological Studies of Ionizing Radiation Exposure.Radiation research · 2024Review
- Review of the risk of cancer following low and moderate doses of sparsely ionising radiation received in early life in groups with individually estimated doses.Environment international · 2022Review
- THYROID SCREENING AND RELIABILITY OF RADIATION THYROID DOSES FOR THE BELARUSIAN IN UTERO COHORT.Problemy radiatsiinoi medytsyny ta radiobiolohii · 2021Article
- Mortality among individuals exposed to atomic bomb radiation in utero: 1950-2012.European journal of epidemiology · 2021Article
- Article
- Belarusian in utero cohort: A new opportunity to evaluate the health effects of prenatal and early-life exposure to ionising radiation.Journal of radiological protection : official journal of the Society for Radiological Protection · 2020Article
- Health Impacts of Low-Dose Ionizing Radiation: Current Scientific Debates and Regulatory Issues.Dose-response : a publication of International Hormesis SocietyReview
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundIt is scientifically uncertain whether in utero exposure to low-dose ionising radiation increases the lifetime risk of haematological malignancies.
methodsWe pooled two cohorts from the Southern Urals comprising offspring of female workers of a large nuclear facility (the Mayak Production Association) and of women living in areas along the Techa River contaminated by nuclear accidents/waste from the same facility, with detailed dosimetry.
resultsThe combined cohort totalled 19 536 subjects with 700 504 person-years at risk over the period of incidence follow-up, and slightly more over the period of mortality follow-up, yielding 58 incident cases and 36 deaths up to age 61 years. Risk was increased in subjects who received in utero doses of ⩾80 mGy (excess relative risk (ERR): 1.27; 95% confidence interval (CI): -0.20 to 4.71), and the risk increased consistently per 100 mGy of continuous exposure in utero (ERR: 0.77; CI: 0.02 to 2.56). No association was apparent in mortality-based analyses. Results for leukaemia and lymphoma were similar. A very weak positive association was observed between incidence and postnatal exposure.
conclusionsIn summary, the results suggest a positive association between in utero exposure to ionising radiation and risk of haematological malignancies, but the small number of outcomes and inconsistent incidence and mortality findings preclude firm conclusions.
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