Evidence map›Paper›PMID 27855279›Full record

ArticleThe American journal of pathology2017

Chronic Phenotype Characterization of a Large-Animal Model of Hereditary Tyrosinemia Type 1.

Faysal Elgilani, Shennen A Mao, Jaime M Glorioso, Meng Yin, Ianko D Iankov, Anisha Singh, Bruce Amiot, Piero Rinaldo, Ronald J Marler, Richard L Ehman and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in The American journal of pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
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  7. Development of Ectopic Livers by Hepatocyte Transplantation Into Swine Lymph Nodes.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2020
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  8. Molecular therapy. Methods & clinical development · 2020
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  9. Using CRISPR/Cas9 to model human liver disease.JHEP reports : innovation in hepatology · 2019
    Review
  10. Hepatotoxicity and Toxicology ofHuman gene therapy. Clinical development · 2019
    Article
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Faysal ElgilaniWilliam J. von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, Minnesota.
Shennen A MaoDepartment of Surgery, Mayo Clinic, Rochester, Minnesota.
Jaime M GloriosoDepartment of Surgery, Mayo Clinic, Rochester, Minnesota.
Meng YinDepartment of Radiology, Mayo Clinic, Rochester, Minnesota.
Ianko D IankovDivision of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.
Anisha SinghDepartment of Surgery, Mayo Clinic, Rochester, Minnesota.
Bruce AmiotBrami Biomedical, Inc., Minneapolis, Minnesota.
Piero RinaldoDivision of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.
Ronald J MarlerDepartment of Comparative Medicine, Mayo Clinic, Scottsdale, Arizona.
Richard L EhmanDepartment of Radiology, Mayo Clinic, Rochester, Minnesota.
Markus GrompePapé Family Pediatric Research Institute, Oregon Health and Science University, Portland, Oregon.
Joseph B LillegardDepartment of Surgery, Mayo Clinic, Rochester, Minnesota; Midwest Fetal Care Center, Children's Hospital and Clinics of Minnesota, Minneapolis, Minnesota.
Raymond D HickeyDepartment of Surgery, Mayo Clinic, Rochester, Minnesota; Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota.
Scott L NybergWilliam J. von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, Minnesota; Department of Surgery, Mayo Clinic, Rochester, Minnesota. Electronic address: nyberg.scott@mayo.edu.
Mayo Clinic · USMayo Clinic in Arizona · USOregon Health & Science University · US

Funding

PILOT AND FEASIBILTY PROGRAMP30DK084567 · NIDDK · MAYO CLINIC ROCHESTER · PI GREGORY J. GORES · 2009 to 2026
$22.2M
Comprehensive noninvasive assessment of liver histopathology in nonalcoholic fatty liver disease (NAFLD) via magnetic resonance imaging, cytometry and elastography (MR-ICE)R01EB017197 · NIBIB · MAYO CLINIC ROCHESTER · PI YIN, MENG · 2014 to 2025
$4.3M
Magnetic Resonance ElastographyR37EB001981 · NIBIB · MAYO CLINIC ROCHESTER · PI EHMAN, RICHARD L. · 2016 to 2025
$4.0M
Magnetic Resonance ElastographyR01EB001981 · NIBIB · MAYO CLINIC ROCHESTER · PI EHMAN, RICHARD L. · 2003 to 2013
$3.1M
Immunodeficient FAH-/- PigsR01DK106667 · NIDDK · MAYO CLINIC ROCHESTER · PI NYBERG, SCOTT L · 2015 to 2019
$2.1M
FAH-Deficient PigsR41DK092105 · NIDDK · YECURIS CORPORATION · PI NYBERG, SCOTT L · 2011 to 2011
$212k
NIBIB NIH HHS R01 EB001981NIBIB NIH HHS R01 EB017197NIBIB NIH HHS R37 EB001981NIDDK NIH HHS P30 DK084567NIDDK NIH HHS R01 DK106667NIDDK NIH HHS R41 DK092105
6 · The paper itself

Abstract

Hereditary tyrosinemia type 1 (HT1) is an autosomal recessive disease caused by deficiency in fumarylacetoacetate hydrolase, the last enzyme in the tyrosine catabolic pathway. In this study, we investigated whether fumarylacetoacetate hydrolase deficient (FAH

Indexed as

AnimalsChronic DiseaseDisease Models, AnimalElasticity Imaging TechniquesFemaleHeptanoatesHumansHydrolasesKidneyLiverLiver CirrhosisMagnetic Resonance SpectroscopyMaleMetabolic Networks and PathwaysPhenotypePortal PressurefumarylacetoacetaseHeptanoatesHydrolasessuccinylacetoneTyrosine

Identifiers

PMID27855279
PMCPMC5225308
OpenAlexW2550707978

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.