ArticlePloS one2016
Genetic Modulation of c-di-GMP Turnover Affects Multiple Virulence Traits and Bacterial Virulence in Rice Pathogen Dickeya zeae.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- The MarR Family Transcriptional Regulator EmrR Negatively Regulates the Type III Secretion System (T3SS) and Positively Modulates Pathogenicity in Dickeya oryzae.Molecular plant pathology · 2026Article
- Article
- A Lrp/AsnC Family Transcriptional Regulator Lrp Is Essential for the Pathogenicity of Dickeya oryzae.Molecular plant pathology · 2025Article
- Newly identified c-di-GMP pathway putative EAL domain gene STM0343 regulates stress resistance and virulence in Salmonella enterica serovar Typhimurium.Veterinary research · 2025Article
- Looking for Resistance to Soft Rot Disease of Potatoes Facing Environmental Hypoxia.International journal of molecular sciences · 2024Review
- Comparative Pathogenomic Analysis of Two Banana PathogenicInternational journal of molecular sciences · 2022Article
- The integration host factor regulates multiple virulence pathways in bacterial pathogen Dickeya zeae MS2.Molecular plant pathology · 2022Article
- Cyclic di-GMP modulates sessile-motile phenotypes and virulence in Dickeya oryzae via two PilZ domain receptors.Molecular plant pathology · 2022Article
- Hfq Is a Critical Modulator of Pathogenicity ofMicroorganisms · 2022Article
- Genomic Comparisons and Phenotypic Diversity ofFrontiers in plant science · 2022Article
- Genomic and phenotypic biology of a novelFrontiers in microbiology · 2022Article
- Two-component system ArcBA modulates cell motility and biofilm formation inFrontiers in plant science · 2022Article
- Dickeya Manipulates Multiple Quorum Sensing Systems to Control Virulence and Collective Behaviors.Frontiers in plant science · 2022Review
- OhrR is a central transcriptional regulator of virulence in Dickeya zeae.Molecular plant pathology · 2022Article
- Genomic and Phenotypic Biology of Novel Strains ofFrontiers in plant science · 2021Article
- Systematic Analysis of c-di-GMP Signaling Mechanisms and Biological Functions in Dickeya zeae EC1.mBio · 2020Article
- Dickeya zeae strains isolated from rice, banana and clivia rot plants show great virulence differentials.BMC microbiology · 2018Article
- Fis is a global regulator critical for modulation of virulence factor production and pathogenicity of Dickeya zeae.Scientific reports · 2018Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The frequent outbreaks of rice foot rot disease caused by Dickeya zeae have become a significant concern in rice planting regions and countries, but the regulatory mechanisms that govern the virulence of this important pathogen remain vague. Given that the second messenger cyclic di-GMP (c-di-GMP) is associated with modulation of various virulence-related traits in various microorganisms, here we set to investigate the role of the genes encoding c-di-GMP metabolism in the regulation of the bacterial physiology and virulence by construction all in-frame deletion mutants targeting the annotated c-di-GMP turnover genes in D. zeae strain EC1. Phenotype analyses identified individual mutants showing altered production of exoenzymes and phytotoxins, biofilm formation and bacterial motilities. The results provide useful clues and a valuable toolkit for further characterization and dissection of the regulatory complex that modulates the pathogenesis and persistence of this important bacterial pathogen.
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