Observational studyPediatric research2017
Heart rate variability in hypoxic ischemic encephalopathy during therapeutic hypothermia.
Observational study in Pediatric research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Severity of hypoxic ischemic encephalopathy and heart rate variability in neonates: a systematic review.BMC pediatrics · 2019Pooled it
- Cardiorespiratory measures shortly after extubation and extubation outcomes in extremely preterm infants.Pediatric research · 2023Trial
- Assessment of parasympathetic tone during therapeutic hypothermia in infants with brain injury following neonatal encephalopathy.Pediatric research · 2026Observational
- CoolCuddle and Autonomic Regulation in Infants With Hypoxic-Ischaemic Encephalopathy: An Intervention Study.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Association between cardiovascular care and neurodevelopmental outcomes in infants with neonatal encephalopathy and hemodynamic instability.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Incidence and Predictors of Later Epilepsy in Neonates with Encephalopathy: The Impact of Electrographic Seizures.Epilepsia open · 2025Observational
- Optimal neuromonitoring techniques in neonates with hypoxic ischemic encephalopathy.Frontiers in pediatrics · 2023Review
- Non-invasive continuous cardiac output monitoring in infants with hypoxic ischaemic encephalopathy.Journal of perinatology : official journal of the California Perinatal Association · 2022Observational
- Hypothermia and heart rate variability in a healthy newborn piglet model.Scientific reports · 2022Article
- Heart rate variability analysis for the prediction of EEG grade in infants with hypoxic ischaemic encephalopathy within the first 12 h of birth.Frontiers in pediatrics · 2022Article
- Neonatal heart rate variability: a contemporary scoping review of analysis methods and clinical applications.BMJ open · 2021Article
- Multichannel EEG abnormalities during the first 6 hours in infants with mild hypoxic-ischaemic encephalopathy.Pediatric research · 2021Article
- Early prognostication of neurological outcome by heart rate variability in adult patients with out-of-hospital sudden cardiac arrest.Critical care (London, England) · 2019Observational
- Heart rate variability and inflammatory markers in neonates with hypoxic-ischemic encephalopathy.Physiological reports · 2019Article
- Evolving changes in fetal heart rate variability and brain injury after hypoxia-ischaemia in preterm fetal sheep.The Journal of physiology · 2018Article
- Therapeutic Hypothermia: How Can We Optimize This Therapy to Further Improve Outcomes?Clinics in perinatology · 2018Review
- Commentary: Computerised interpretation of fetal heart rate during labour (INFANT): a randomised controlled trial.Frontiers in physiology · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTherapeutic hypothermia (TH) aims to ameliorate further injury in infants with moderate and severe hypoxic ischemic encephalopathy (HIE). We aim to assess the effect of TH on heart rate variability (HRV) in infants with HIE.
methodsMultichannel video-electroencephalography (EEG) and electrocardiography were assessed at 6-72 h after birth in full-term infants with HIE, recruited prior to (pre-TH group) and following (TH group) the introduction of TH in our neonatal unit. HIE severity was graded using EEG. HRV features investigated include: mean NN interval (mean NN), standard deviation of NN interval (SDNN), triangular interpolation (TINN), high-frequency (HF), low-frequency (LF), very low-frequency (VLF), and LF/HF ratio. Linear mixed model comparisons were used.
results118 infants (pre-TH: n = 44, TH: n = 74) were assessed. The majority of HRV features decreased with increasing EEG grade. Infants with moderate HIE undergoing TH had significantly different HRV features compared with the pre-TH group (HF: P = 0.016, LF/HF ratio: P = 0.006). In the pre-TH group, LF/HF ratio was significantly different between moderate and severe HIE grades (P = 0.002). In the TH group, significant differences were observed between moderate and severe HIE grades for SDNN: P = 0.020, TINN: P = 0.005, VLF: P = 0.029, LF: P = 0.010, and HF: P = 0.006.
conclusionThe HF component of HRV is increased in infants with moderate HIE undergoing TH.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.