ArticleAmerican journal of respiratory and critical care medicine2017
Acute Kidney Injury as a Risk Factor for Delirium and Coma during Critical Illness.
Article in American journal of respiratory and critical care medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 4 of them syntheses that pooled it.
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Who cites it
69 citing papers in PubMed, 4 syntheses or guidelines pooled it, 113 citations in OpenAlex.
- Acute Kidney Injury and Risk of Adverse Neurocognitive Outcomes: A Systematic Review and Meta-Analysis.Neurology · 2026Pooled it
- Guidelines for Neuroprognostication in Critically ill Adults with Acute Ischemic Stroke.Neurocritical care · 2026Guideline
- Factors contributing to sepsis-associated encephalopathy: a comprehensive systematic review and meta-analysis.Frontiers in medicine · 2024Pooled it
- Predisposing and Precipitating Factors Associated With Delirium: A Systematic Review.JAMA network open · 2023Pooled it
- Association between ePWV and delirium risk in icu sepsis patients: a retrospective analysis based on the MIMIC database and development of a predictive model.Clinics (Sao Paulo, Brazil) · 2026Article
- AKI as a systemic syndrome and its impact on other organ systems.Critical care (London, England) · 2026Review
- Glymphatic dysfunction: a unifying hypothesis for delirium.Nature reviews. Neurology · 2026Review
- Clinical Outcomes and Mortality Following Delirium: A Five-Year Follow-Up Study on Hospitalized Patients.Journal of clinical medicine · 2026Article
- Association between acute kidney injury and delirium in critically ill patients: a retrospective cohort study using two independent databases.Critical care (London, England) · 2026Article
- Research advances on acute kidney injury and brain dysfunction.Frontiers in nephrology · 2026Review
- A machine learning-based prediction model for sepsis-associated delirium in intensive care unit patients with sepsis-associated acute kidney injury.Renal failure · 2025Observational
- Acute kidney injury and postoperative delirium.Journal of biomedical research · 2025Article
- A Data-Driven Model to Predict Delirium Based on Dynamic Patterns of Clinical Deterioration in Critically Ill Patients.Nursing in critical care · 2025Article
- Association of Plasma BDNF Concentration and Val66Met Polymorphism with Postoperative Delirium After Cardiac Surgery Under General Anesthesia with Cardiopulmonary Bypass.Journal of clinical medicine · 2025Article
- The Prevalence, Risk Factors, and Short-Term Health Outcomes of Delirium in Patients Admitted to a Nephrology Ward in Eastern Europe: An Observational Prospective Cohort Study.Journal of clinical medicine · 2025Article
- Association between acute kidney injury, delirium and outcomes in patients with critical illness: a protocol for a systematic review.BMJ open · 2025Article
- Holistic Patient-Centered Outcomes in Post-Acute Kidney Injury Care: Physical, Emotional, Cognitive, and Social Outcomes.Advances in kidney disease and health · 2025Review
- A machine learning model based on emergency clinical data predicting 3-day in-hospital mortality for stroke and trauma patients.Frontiers in neurology · 2025Article
- Association Between Blood Urea Nitrogen and Delirium in Critically Ill Elderly Patients Without Kidney Diseases: A Retrospective Study and Mendelian Randomization Analysis.CNS neuroscience & therapeutics · 2025Article
- Clinical Characteristics Associated With Hospital Mortality and Length of Stay Among Older Adults Admitted With Delirium: Retrospective Analysis.HCA healthcare journal of medicine · 2025Article
9 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
rationaleAcute kidney injury may contribute to distant organ dysfunction. Few studies have examined kidney injury as a risk factor for delirium and coma.
objectivesTo examine whether acute kidney injury is associated with delirium and coma in critically ill adults.
methodsIn a prospective cohort study of intensive care unit patients with respiratory failure and/or shock, we examined the association between acute kidney injury and daily mental status using multinomial transition models adjusting for demographics, nonrenal organ failure, sepsis, prior mental status, and sedative exposure. Acute kidney injury was characterized daily using the difference between baseline and peak serum creatinine and staged according to Kidney Disease Improving Global Outcomes criteria. Mental status (normal vs. delirium vs. coma) was assessed daily with the Confusion Assessment Method for the ICU and Richmond Agitation-Sedation Scale. MEASUREMENTS AND MAIN
resultsAmong 466 patients, stage 2 acute kidney injury was a risk factor for delirium (odds ratio [OR], 1.55; 95% confidence interval [CI], 1.07-2.26) and coma (OR, 2.04; 95% CI, 1.25-3.34) as was stage 3 injury (OR for delirium, 2.56; 95% CI, 1.57-4.16) (OR for coma, 3.34; 95% CI, 1.85-6.03). Daily peak serum creatinine (adjusted for baseline) values were also associated with delirium (OR, 1.35; 95% CI, 1.18-1.55) and coma (OR, 1.44; 95% CI, 1.20-1.74). Renal replacement therapy modified the association between stage 3 acute kidney injury and daily peak serum creatinine and both delirium and coma.
conclusionsAcute kidney injury is a risk factor for delirium and coma during critical illness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.