ArticleAmerican journal of respiratory cell and molecular biology2017
Sex-Based Genetic Association Study Identifies CELSR1 as a Possible Chronic Obstructive Pulmonary Disease Risk Locus among Women.
Article in American journal of respiratory cell and molecular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- X chromosome associations with chronic obstructive pulmonary disease and related phenotypes: an X chromosome-wide association study.Respiratory research · 2023Pooled it
- Smoking as an independent predictor of long term care certification: The Yamagata cohort study.Tobacco induced diseases · 2026Article
- Sex and disease regulate major histocompatibility complex class I expression in human lung epithelial cells.Physiological reports · 2024Article
- A bronchial gene signature specific for severe COPD that is retained in the nose.ERJ open research · 2023Article
- Differences in chronic obstructive pulmonary disease among US nursing home residents with heart failure according to sex and type of heart failure.The clinical respiratory journal · 2023Article
- Sex and Gender Omic Biomarkers in Men and Women With COPD: Considerations for Precision Medicine.Chest · 2021Review
- Gene-Based Analysis Reveals Sex-Specific Genetic Risk Factors of COPD.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2021Article
- Smoking Pattern in Men and Women: A Possible Contributor to Sex Differences in Smoke-related Lung Diseases.American journal of respiratory and critical care medicine · 2020Article
- Bayesian reassessment of the epigenetic architecture of complex traits.Nature communications · 2020Article
- Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine.The Journal of pathology · 2020Review
- Noncanonical Wnt planar cell polarity signaling in lung development and disease.Biochemical Society transactions · 2020Review
- Chronic Obstructive Pulmonary Disease in Women: A Biologically Focused Review with a Systematic Search Strategy.International journal of chronic obstructive pulmonary disease · 2020Review
- Genetic Advances in Chronic Obstructive Pulmonary Disease. Insights from COPDGene.American journal of respiratory and critical care medicine · 2019Review
- Personal carbon monoxide exposure, respiratory symptoms, and the potentially modifying roles of sex and HIV infection in rural Uganda: a cohort study.Environmental health : a global access science source · 2019Article
- Prevalence and correlates of chronic obstructive pulmonary disease and chronic respiratory symptoms in rural southwestern Uganda: a cross-sectional, population-based study.Journal of global health · 2019Article
- Dynamic changes in lung responses after single and repeated exposures to cigarette smoke in mice.PloS one · 2019Article
- The etiologic origins for chronic obstructive pulmonary disease.International journal of chronic obstructive pulmonary disease · 2019Review
- Update in Chronic Obstructive Pulmonary Disease 2017.American journal of respiratory and critical care medicine · 2018Article
- HIV Infection, Pulmonary Tuberculosis, and COPD in Rural Uganda: A Cross-Sectional Study.Lung · 2018Article
- Gene expression profile of human lung in a relatively early stage of COPD with emphysema.International journal of chronic obstructive pulmonary disease · 2018Article
Corrections and comments
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Authors and funding
25 authors at 11 institutions in 4 countries.
Funding
Abstract
Chronic obstructive pulmonary disease (COPD) is a complex disease with strong environmental and genetic influences and sexually dimorphic features. Although genetic risk factors for COPD have been identified, much of the heritability remains unexplained. Sex-based genetic association studies may uncover additional COPD genetic risk factors. We studied current and former smokers from COPD case-control cohorts (COPDGene non-Hispanic whites and African Americans, Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-Points, and Genetics of Chronic Obstructive Lung Disease). COPD was defined as post-bronchodilator forced expiratory volume in 1 second/forced vital capacity less than 0.70 and forced expiratory volume in 1 second percent predicted less than 80. Testing was performed across all cohorts and combined in a meta-analysis adjusted for age, pack-years, and genetic ancestry. We first performed genome-wide single-nucleotide polymorphism (SNP)-by-sex interaction testing on the outcome of COPD affection status. We performed sex-stratified association testing for SNPs with interaction P less than 10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.