ArticleBehavioral neuroscience2016
Ventral striatal lesions disrupt dopamine neuron signaling of differences in cue value caused by changes in reward timing but not number.
Article in Behavioral neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Neuronal implementation of the temporal difference learning algorithm in the midbrain dopaminergic system.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Mesoaccumbal Dopamine Heterogeneity: What Do Dopamine Firing and Release Have to Do with It?Annual review of neuroscience · 2022Review
- Neural substrates of appetitive and aversive prediction error.Neuroscience and biobehavioral reviews · 2021Review
- Previous cocaine self-administration disrupts reward expectancy encoding in ventral striatum.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
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Authors and funding
2 authors.
Funding
Abstract
We recently showed that ventral striatal (VS) lesions abolished reward prediction errors that reflect changes in reward timing while leaving relatively unaffected errors that reflect changes in reward number. Here we extended those results by examining whether normal learning-related changes in firing to the reward-predictive cues in the same dopamine neurons were also disrupted by VS lesions. This analysis revealed that dopamine neurons recorded in VS-lesioned rats failed to show value-related changes in firing to the cues in timing but showed normal changes in number blocks. This effect suggests that the loss of reward-evoked error signals in the timing blocks impaired encoding of the cue value in downstream areas, which then supply these predictions to dopamine neurons at the time of cue presentation. (PsycINFO Database Record
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.