Trial reportNutrients2016
Black Tea Increases Circulating Endothelial Progenitor Cells and Improves Flow Mediated Dilatation Counteracting Deleterious Effects from a Fat Load in Hypertensive Patients: A Randomized Controlled Study.
Trial report in Nutrients, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A single, high-fat meal adversely affects postprandial endothelial function: a systematic review and meta-analysis.The American journal of clinical nutrition · 2022Pooled it
- Positive Effects of Tomato Paste on Vascular Function After a Fat Meal in Male Healthy Subjects.Nutrients · 2018Trial
- Angiogenesis as a Therapeutic Target of (Poly)phenols: Tackling Cancer and Vascular-Related Complications.Molecular nutrition & food research · 2025Review
- Health-Promoting Effects of Black Tea: A Narrative Review of Clinical Trials.International journal of food science · 2025Review
- From a Cup of Tea to Cardiovascular Care: Vascular Mechanisms of Action.Life (Basel, Switzerland) · 2024Review
- Nailfold Capillaroscopy: A Comprehensive Review on Its Usefulness in Both Clinical Diagnosis and Improving Unhealthy Dietary Lifestyles.Nutrients · 2024Review
- Targeting oxidative stress as a preventive and therapeutic approach for cardiovascular disease.Journal of translational medicine · 2023Review
- Protective effects and molecular mechanisms of tea polyphenols on cardiovascular diseases.Frontiers in nutrition · 2023Review
- Acute and Long Term Effects of a Nutraceutical Combination on Lipid Profile, Glucose Metabolism and Vascular Function in Patients with Dyslipidaemia with and Without Cigarette Smoking.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2021Article
- Date Palm Fruit (International journal of molecular sciences · 2021Review
- Modulation of Adhesion Process, E-Selectin and VEGF Production by Anthocyanins and Their Metabolites in anNutrients · 2020Article
- Role of Polyphenols and Carotenoids in Endothelial Dysfunction: An Overview from Classic to Innovative Biomarkers.Oxidative medicine and cellular longevity · 2020Review
- Health Functions and Related Molecular Mechanisms of Tea Components: An Update Review.International journal of molecular sciences · 2019Review
- Tea consumption is associated with a reduced risk of coronary heart disease in female but not male populations in Guangzhou, China.Nutrition research and practice · 2019Article
- Coffee and Endothelial Function: A Coffee Paradox?Nutrients · 2019Review
- Effects and Mechanisms of Tea and Its Bioactive Compounds for the Prevention and Treatment of Cardiovascular Diseases: An Updated Review.Antioxidants (Basel, Switzerland) · 2019Review
- The Effects of Flavonoids on Cardiovascular Health: A Review of Human Intervention Trials and Implications for Cerebrovascular Function.Nutrients · 2018Review
- Endothelial progenitor cells in age-related vascular remodeling.Cell transplantation · 2018Review
- Black tea and maintenance of normal endothelium-dependent vasodilation: evaluation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006.EFSA journal. European Food Safety Authority · 2018Article
- Studies on prevention of obesity, metabolic syndrome, diabetes, cardiovascular diseases and cancer by tea.Journal of food and drug analysis · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
(1) Background: Endothelial dysfunction predicts cardiovascular events. Circulating angiogenic cells (CACs) maintain and repair the endothelium regulating its function. Tea flavonoids reduce cardiovascular risk. We investigated the effects of black tea on the number of CACs and on flow-mediated dilation (FMD) before and after an oral fat in hypertensives; (2) Methods: In a randomized, double-blind, controlled, cross-over study, 19 patients were assigned to black tea (150 mg polyphenols) or a placebo twice a day for eight days. Measurements were obtained in a fasted state and after consuming whipping cream, and FMD was measured at baseline and after consumption of the products; (3) Results: Compared with the placebo, black tea ingestion increased functionally active CACs (36 ± 22 vs. 56 ± 21 cells per high-power field;
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.