ReviewToxins2016
N-methyl-2-pyridone-5-carboxamide (2PY)-Major Metabolite of Nicotinamide: An Update on an Old Uremic Toxin.
Open access · goldAbstract readReview
In one paragraph
Review in Toxins, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk.Nature medicine · 2024Pooled it
- A machine learning approach to metabolomics identifies putative biomarker candidates and dysregulated pathways for distinguishing gout from asymptomatic hyperuricemia in the Zhuang population.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Plasma metabolomics analysis in murine prerenal azotemia reveals changes in energy substrates, amino acid metabolism, and uremic toxins.American journal of physiology. Renal physiology · 2026Article
- Novel applications of SIRT1 in Chronic Kidney Disease.Frontiers in medicine · 2026Review
- Identification of potential NAD-related biomarkers of recurrent miscarriage risk.Human reproduction (Oxford, England) · 2025Article
- Intergenerational Associations of Hypertensive Disorders of Pregnancy With Offspring Metabolomics: A Systematic Review.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2025Article
- High Concentrations of Circulating 2PY and 4PY-Potential Risk Factor of Cardiovascular Disease in Patients with Chronic Kidney Disease.International journal of molecular sciences · 2025Review
- Proton pump inhibitors reduce survival outcomes in patients treated with capecitabine: meta-analysis.Ecancermedicalscience · 2025Review
- Dysregulated nicotinamide adenine dinucleotide metabolome in patients hospitalized with COVID-19.Aging cell · 2024Article
- NAD metabolism and heart failure: Mechanisms and therapeutic potentials.Journal of molecular and cellular cardiology · 2024Review
- Regulation of and challenges in targeting NADNature reviews. Molecular cell biology · 2024Review
- Explainable AI-prioritized plasma and fecal metabolites in inflammatory bowel disease and their dietary associations.iScience · 2024Article
- Nicotinamide N-Methyltransferase (NNMT): A New Hope for Treating Aging and Age-Related Conditions.Metabolites · 2024Review
- The Brain Metabolome Is Modified by Obesity in a Sex-Dependent Manner.International journal of molecular sciences · 2024Article
- Impact of Pregnancy on the Pharmacokinetics and Metabolism of Nicotinamide in Humans.Clinical pharmacology and therapeutics · 2024Article
- Elevated Plasma Concentration of 4-Pyridone-3-carboxamide-1-β-D-ribonucleoside (4PYR) Highlights Malignancy of Renal Cell Carcinoma.International journal of molecular sciences · 2024Article
- Delayed metabolic disturbances in the myocardium after exertional heat stroke: contrasting effects of exertion and thermal load.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- N-methyl-2-pyridone-5-carboxamide (N-Me-2PY) has potent anti-fibrotic and anti-inflammatory activity in a fibrotic kidney model: is it an old uremic toxin?Clinical and experimental nephrology · 2023Article
- The complexity of nicotinamide adenine dinucleotide (NAD), hypoxic, and aryl hydrocarbon receptor cell signaling in chronic kidney disease.Journal of translational medicine · 2023Review
- Defining NAD(P)(H) Catabolism.Nutrients · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Aurélie LengletInstitut National de la Santé et de la Recherche Médicale (INSERM U-1088), Jules Verne University of Picardie, Amiens 80000, France. terrier-lenglet.aurelie@chu-amiens.fr.
Sophie LiabeufInstitut National de la Santé et de la Recherche Médicale (INSERM U-1088), Jules Verne University of Picardie, Amiens 80000, France. liabeuf.sophie@chu-amiens.fr.
Sandra BodeauInstitut National de la Santé et de la Recherche Médicale (INSERM U-1088), Jules Verne University of Picardie, Amiens 80000, France. bodeau.sandra@chu-amiens.fr.
Loïc LouvetInstitut National de la Santé et de la Recherche Médicale (INSERM U-1088), Jules Verne University of Picardie, Amiens 80000, France. loic.louvet@u-picardie.fr.
Aurélien MaryInstitut National de la Santé et de la Recherche Médicale (INSERM U-1088), Jules Verne University of Picardie, Amiens 80000, France. mary.aurelien@chu-amiens.fr.
Agnès BoullierInstitut National de la Santé et de la Recherche Médicale (INSERM U-1088), Jules Verne University of Picardie, Amiens 80000, France. agnes.boullier@u-picardie.fr.
Anne Sophie Lemaire-HurtelLaboratory of Pharmacology and Toxicology, Amiens University Medical Center, Amiens 80000, France. lemaire-hurtel.anne-sophie@chu-amiens.fr.
Alexia JonetLaboratory of Glycochimie, des Antimicrobiens et des Agroressouces, Unité Mixte de Recherche-Centre National de la Recherché Scientifique (UMR CNRS) 7378, UFR de Pharmacy, Jules Verne University of Picardie, Amiens 80000, France. alexia.jonet@u-picardie.fr.
Pascal SonnetLaboratory of Glycochimie, des Antimicrobiens et des Agroressouces, Unité Mixte de Recherche-Centre National de la Recherché Scientifique (UMR CNRS) 7378, UFR de Pharmacy, Jules Verne University of Picardie, Amiens 80000, France. pascal.sonnet@u-picardie.fr.
Said KamelInstitut National de la Santé et de la Recherche Médicale (INSERM U-1088), Jules Verne University of Picardie, Amiens 80000, France. said.kamel@u-picardie.fr.
Ziad A MassyDivision of Nephrology, Ambroise Paré University Medical Center, Assistance Publique-Hôpitaux de Paris APHP, Boulogne, Billancourt, Paris 92100, France. ziad.massy@aphp.fr.
Inserm · FRCentre National de la Recherche Scientifique · FRCentre Hospitalier Universitaire Amiens-Picardie · FR
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
AnimalsHumansNiacinamideRenal Insufficiency, ChronicToxins, BiologicalUremiaNiacinamideN'-methyl-2-pyridone-5-carboxamideToxins, Biologicalchronic kidney diseaseniacinnicotinamideN-methyl-2-pyridone-5-carboxamideuremic toxin
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.