ArticleMolecules (Basel, Switzerland)2016
Natural Deep Eutectic Solvents (NADES) as a Tool for Bioavailability Improvement: Pharmacokinetics of Rutin Dissolved in Proline/Glycine after Oral Administration in Rats: Possible Application in Nutraceuticals.
Article in Molecules (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
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Who cites it
55 citing papers in PubMed, 222 citations in OpenAlex.
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- Optimization of Extraction and Antioxidant Activities of Resveratrol fromMolecules (Basel, Switzerland) · 2026Article
- Menthol-Fatty Acid HDES Boosts In Vitro Oral Bioavailability of Oleanolic Acid via Synergistic Digestive Release and Cellular Absorption.Foods (Basel, Switzerland) · 2026Article
- COSMO-RS prediction and validation of gingerol and shogaol extraction from Zingiber officinale var. rubrum using natural deep eutectic solvents.Scientific reports · 2025Article
- Green extraction of poplar type propolis: ultrasonic extraction parameters and optimization via response surface methodology.BMC chemistry · 2025Article
- Natural deep eutectic solvents (NaDES): green solvents for pharmaceutical applications and beyond.Green chemistry : an international journal and green chemistry resource : GC · 2025Review
- Polyphenol-enriched extraction fromRSC advances · 2025Article
- The Role of Natural Deep Eutectic Solvents in a Hydrogel Formulation Containing Lidocaine.Pharmaceutics · 2025Article
- An Overview on the Role of Ionic Liquids and Deep Eutectic Solvents in Oral Pharmaceuticals.Pharmaceutics · 2025Review
- Application of Hansen solubility parameters in the eutectic mixtures: difference between empirical and semi-empirical models.Scientific reports · 2025Article
- Phenolic Characterization and Quality Evaluation of Herbal Coffee from Roasted Juniper Berry Fruits (Foods (Basel, Switzerland) · 2024Article
- Design of Eutectic Solvents with Specified Extraction Properties Based on Intermolecular Interaction Energy.Molecules (Basel, Switzerland) · 2024Article
- Advances in Extracting Bioactive Compounds from Food and Agricultural Waste and By-Products Using Natural Deep Eutectic Solvents: A Circular Economy Perspective.Molecules (Basel, Switzerland) · 2024Review
- Pharmaceutical applications of therapeutic deep eutectic systems (THEDES) in maximising drug delivery.Heliyon · 2024Review
- Optimization and Validation of Procyanidins Extraction and Phytochemical Profiling of Seven Herbal Matrices of Nutraceutical Interest.Antioxidants (Basel, Switzerland) · 2024Article
- Review
- NaDES Application in Cosmetic and Pharmaceutical Fields: An Overview.Gels (Basel, Switzerland) · 2024Review
- From Nature to Innovation: The Uncharted Potential of Natural Deep Eutectic Solvents.Molecules (Basel, Switzerland) · 2023Review
- Green Extraction of Polyphenols via Deep Eutectic Solvents and Assisted Technologies from Agri-Food By-Products.Molecules (Basel, Switzerland) · 2023Review
- Effect of Deep Eutectic System (DES) on Oral Bioavailability of Celecoxib: In Silico, In Vitro, and In Vivo Study.Pharmaceutics · 2023Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is a need for innovation in plant-derived pharmaceuticals, food supplements and nutraceutical products regarding the use of more eco-sustainable solvents for their extraction. Furthermore, the poor oral bioavailability of several phytochemicals with health promoting effects stimulates the research in the field of pharmaceutical formulations. Natural Deep Eutectic Solvents (NADES) are formed by natural compounds, and can be considered as future solvents being especially useful for the preparation of nutraceuticals and food-grade extracts. In this paper various NADES were prepared using sugars, aminoacids and organic acids. Rutin (quercetin-3-
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.