Evidence map›Paper›PMID 27854206›Full record

ArticleJournal of neuromuscular diseases2016

Sexual Reassignment Fails to Prevent Kennedy's Disease.

Tyler A Lanman, Dara Bakar, Nisha M Badders, Ailbhe Burke, Angela Kokkinis, Joseph A Shrader, Galen O Joe, Alice B Schindler, Laura C Bott, George G Harmison and 3 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuromuscular diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Neurological care for LGBT+ people.Nature reviews. Neurology · 2024
    Review
  3. Article
  4. Article
  5. Review
  6. Molecular Mechanisms and Therapeutics for SBMA/Kennedy's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2019
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Tyler A LanmanNeurogenetics Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA.
Dara BakarNeurogenetics Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA.
Nisha M BaddersHoward Hughes Medical Institute, Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Ailbhe BurkeInstitute of Neurology, University College London, Queen Square, London WC1N 3BG, UK.
Angela KokkinisNeurogenetics Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA.
Joseph A ShraderDepartment of Rehabilitation Medicine, Clinical Center, Department of Health and Human Services, NIH, Bethesda, MD, USA.
Galen O JoeDepartment of Rehabilitation Medicine, Clinical Center, Department of Health and Human Services, NIH, Bethesda, MD, USA.
Alice B SchindlerNeurogenetics Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA.
Laura C BottNeurogenetics Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA.
George G HarmisonNeurogenetics Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA.
J Paul TaylorHoward Hughes Medical Institute, Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Kenneth H FischbeckNeurogenetics Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA.
Christopher GrunseichNeurogenetics Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA.

Funding

Intramural NIH HHS Z99 CL999999
6 · The paper itself

Abstract

Spinal and bulbar muscular atrophy is caused by polyglutamine expansion in the androgen receptor. As an X-linked disease dependent on androgens, symptoms and findings are only fully manifest in males. Here we describe a 40-year-old male-to-female transgender SBMA patient who developed full disease manifestations despite undetectable levels of androgens. We used cell culture and animal models to show that spironolactone, the anti-androgen she had taken for 15 years, promotes nuclear localization and toxicity of the mutant protein, which may explain the disease manifestations in this patient.

Indexed as

Androgen AntagonistsAnimalsBulbo-Spinal Atrophy, X-LinkedDisease Models, AnimalDrosophilaFemaleGender-Affirming ProceduresHumansMaleRatsSpironolactoneTranssexualismAndrogen AntagonistsSpironolactoneandrogenbulbo-spinal atrophyMotor neuron diseasereceptorsspironolactoneX-Linked

Identifiers

PMID27854206
PMCPMC10427994

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.