ArticleAdvances in therapy2017
Impact of Treatment-Related Beliefs on Medication Adherence in Immune-Mediated Inflammatory Diseases: Results of the Global ALIGN Study.
Article in Advances in therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Do visual aids influenced patients' risk perceptions for rare and very rare risks?Patient education and counseling · 2018Trial
- Exploring Pain on Social Media: Observational Study on Perceptions and Discussions of Chronic Pain Conditions.JMIR infodemiology · 2025Observational
- Gene therapy and genome editing for lipoprotein disorders.European heart journal · 2025Review
- Medication Burden Before and After Prescription of Biologics in Patients with Inflammatory Bowel Disease.Journal of clinical medicine · 2024Article
- Clinical and psychological characteristics associated with negative beliefs and concerns about treatment necessity in rheumatic diseases.Scientific reports · 2022Article
- Assessment of Medication Adherence and Pharmacist Intervention Are Important for the Care of Patients with Inflammatory Bowel Disease.Gut and liver · 2022Article
- Applying Machine Learning Models to Predict Medication Nonadherence in Crohn's Disease Maintenance Therapy.Patient preference and adherence · 2020Article
- A portfolio of biologic self-injection devices in rheumatology: how patient involvement in device design can improve treatment experience.Drug delivery · 2019Review
- An overview of the common methods used to measure treatment adherence.Medicine and pharmacy reports · 2019Review
- ALIGNed on adherence: subanalysis of adherence in immune-mediated inflammatory diseases in the DACH region of the global ALIGN study.Journal of the European Academy of Dermatology and Venereology : JEADV · 2019Article
- Predicting adherence to therapy in rheumatoid arthritis, psoriatic arthritis or ankylosing spondylitis: a large cross-sectional study.RMD open · 2019Article
- The beliefs of rheumatoid arthritis patients in their subcutaneous biological drug: strengths and areas of concern.Rheumatology international · 2018Article
- Reliability and validity of a 12-item medication adherence scale for patients with chronic disease in Japan.BMC health services research · 2018Article
- Medication adherence and persistence in patients with autoimmune rheumatic diseases: a narrative review.Patient preference and adherence · 2018Review
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10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionMedication adherence is critical in chronic immune-mediated inflammatory diseases (IMIDs) and could be affected by patients' treatment-related beliefs. The objective of this study was to determine beliefs about systemic medications in patients with IMIDs and to explore the association of those beliefs and other factors with adherence.
methodsThis was a multi-country, cross-sectional, self-administered survey study. Included were adults diagnosed with one of six IMIDs receiving conventional systemic medications and/or tumor necrosis factor inhibitors (TNFi). Patients' necessity beliefs/concerns towards and adherence to treatments were assessed by the Beliefs about Medicines Questionnaire and four-item Morisky Medication Adherence Scale. Correlation of patients' beliefs about treatment and other factors with adherence were evaluated by multivariable regression analyses.
resultsAmong studied patients (N = 7197), 32.0% received TNFi monotherapy, 27.7% received TNFi-conventional combination therapy, and 40.3% received conventional medications. Across IMIDs, high adherence to systemic treatment was more prevalent in TNFi groups (61.3-80.7%) versus corresponding conventional treatment groups (28.4-64.7%). In at least four IMIDs, greater perception of the illness continuing forever (P < 0.001), of the treatment helping (P < 0.001), and more concerns about the illness (P < 0.01), but not clinical parameters, were associated with higher treatment necessity beliefs. Higher treatment necessity beliefs, older age, Caucasian race, and TNFi therapy were associated with high medication adherence in at least four IMIDs.
conclusionsTreatment necessity beliefs were higher than concerns about current medication in patients with IMID. Illness perceptions had a greater impact on treatment necessity beliefs than clinical parameters. Older age, greater treatment necessity beliefs, and TNFi therapy were associated with high self-reported medication adherence in at least four IMIDs.
trial registrationACTRN12612000977875.
fundingAbbVie.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.