Evidence map›Paper›PMID 27853973›Full record

SynthesisTechniques in coloproctology2016

Clinical outcomes and case volume effect of transanal total mesorectal excision for rectal cancer: a systematic review.

C L Deijen, A Tsai, T W A Koedam, M Veltcamp Helbach, C Sietses, A M Lacy, H J Bonjer, J B Tuynman

Abstract readSystematic Review
In one paragraph

Synthesis in Techniques in coloproctology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Meta-analysis of transanalWorld journal of gastrointestinal surgery · 2022
    Article
  15. Article
  16. Mesentery in Transanal TME.Clinics in colon and rectal surgery · 2022
    Review
  17. Article
  18. Review
  19. Article
  20. Article

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

C L DeijenDepartment of Surgery, VU University Medical Centre, PO Box 7057, 1007 MB, Amsterdam, The Netherlands. c.deijen@vumc.nl.
A TsaiDepartment of Surgery and Cancer, Imperial College London, London, UK.
T W A KoedamDepartment of Surgery, VU University Medical Centre, PO Box 7057, 1007 MB, Amsterdam, The Netherlands.
M Veltcamp HelbachDepartment of Surgery, Gelderse Vallei Hospital Ede, Ede, The Netherlands.
C SietsesDepartment of Surgery, Gelderse Vallei Hospital Ede, Ede, The Netherlands.
A M LacyDepartment of Surgery, Hospital Clinic de Barcelona, Barcelona, Spain.
H J BonjerDepartment of Surgery, VU University Medical Centre, PO Box 7057, 1007 MB, Amsterdam, The Netherlands.
J B TuynmanDepartment of Surgery, VU University Medical Centre, PO Box 7057, 1007 MB, Amsterdam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transanal total mesorectal excision (TaTME) has been developed to improve quality of TME for patients with mid and low rectal cancer. However, despite enthusiastic uptake and teaching facilities, concern exists for safe introduction. TaTME is a complex procedure and potentially a learning curve will hamper clinical outcome. With this systematic review, we aim to provide data regarding morbidity and safety of TaTME. A systematic literature search was performed in MEDLINE (PubMed), EMBASE (Ovid) and Cochrane Library. Case reports, cohort series and comparative series on TaTME for rectal cancer were included. To evaluate a potential effect of case volume, low-volume centres (n ≤ 30 total volume) were compared with high-volume centres (n > 30 total volume). Thirty-three studies were identified (three case reports, 25 case series, five comparative studies), including 794 patients. Conversion was performed in 3.0% of the procedures. The complication rate was 40.3, and 11.5% were major complications. The quality of the mesorectum was "complete" in 87.6%, and the circumferential resection margin (CRM) was involved in 4.7%. In low- versus high-volume centres, the conversion rate was 4.3 versus 2.7%, and major complication rates were 12.2 versus 10.5%, respectively. TME quality was "complete" in 80.5 versus 89.7%, and CRM involvement was 4.8 and 4.5% in low- versus high-volume centres, respectively. TaTME for mid and low rectal cancer is a promising technique; however, it is associated with considerable morbidity. Safe implementation of the TaTME should include proctoring and quality assurance preferably within a trial setting.

Indexed as

AgedAged, 80 and overClinical CompetenceConversion to Open SurgeryFemaleHospitals, High-VolumeHospitals, Low-VolumeHumansLearning CurveMaleMesocolonMiddle AgedPostoperative ComplicationsRectal NeoplasmsRectumTransanal Endoscopic SurgeryCase volumeMorbidityRectal cancerTotal mesorectal excisionTransanal

Identifiers

PMID27853973
PMCPMC5156667

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.