ArticleSleep & breathing = Schlaf & Atmung2017
Brain pathway differences between Parkinson's disease patients with and without REM sleep behavior disorder.
Article in Sleep & breathing = Schlaf & Atmung, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Sleep disorders and structural alterations in brain regions linked with motivation: a neuroimaging meta-analysis.Scientific reports · 2026Pooled it
- Gray Matter Alterations in Parkinson's Disease With Rapid Eye Movement Sleep Behavior Disorder: A Meta-Analysis of Voxel-Based Morphometry Studies.Frontiers in aging neuroscience · 2020Pooled it
- Assessing White Matter Pathology in Early-Stage Parkinson Disease Using Diffusion MRI: A Systematic Review.Frontiers in neurology · 2020Pooled it
- Trial
- Separable, symptom specific alterations in brain microstructure associated with early-stage Parkinson's disease.Frontiers in neuroscience · 2026Article
- Behavioral disorders in Parkinson disease: current view.Journal of neural transmission (Vienna, Austria : 1996) · 2025Review
- Multimodal MRI changes associated with non-motor symptoms of rapid eye movement sleep behaviour disorder in Parkinson's disease patients.Neuroradiology · 2025Article
- Serum glial cell line-derived neurotrophic factor: a potential biomarker for white matter alteration in Parkinson's disease with mild cognitive impairment.Frontiers in neuroscience · 2024Article
- The Relationship Between Sleep and Brain Function in Older Adults With Chronic Kidney Disease and Self-Identified Cognitive Impairment.Journal of gerontological nursing · 2023Article
- Review
- MRI findings in movement disorders and associated sleep disturbances.American journal of nuclear medicine and molecular imaging · 2023Review
- Aberrant corticospinal tract characteristics in prodromal PD: A diffusion tensor imaging study.Clinical parkinsonism & related disorders · 2023Article
- White Matter Microstructural Alterations in Newly Diagnosed Parkinson's Disease: A Whole-Brain Analysis Using dMRI.Brain sciences · 2022Article
- White matter tract-specific microstructural disruption is associated with depressive symptoms in isolated RBD.NeuroImage. Clinical · 2022Article
- REM Sleep Behavior Disorder in Parkinson's Disease: Effects on Cognitive, Psychiatric, and Functional outcomes.Journal of the International Neuropsychological Society : JINS · 2020Article
- Association of olfaction dysfunction with brain microstructure in prodromal Parkinson disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Article
- Microstructural Changes in Patients With Parkinson's Disease Comorbid With REM Sleep Behaviour Disorder and Depressive Symptoms.Frontiers in neurology · 2018Article
- Article
- Disruption of Inferior Longitudinal Fasciculus Microstructure in Parkinson's Disease: A Systematic Review of Diffusion Tensor Imaging Studies.Frontiers in neurology · 2018Review
- Structural and Functional Brain Patterns of Non-Motor Syndromes in Parkinson's Disease.Frontiers in neurology · 2018Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeREM (rapid eye movement) sleep behavior disorder (RBD) is characterized by increased muscle tone and violent limb movements and is a usual symptom of the early stages of Parkinson's disease (PD). PD patients with RBD represent faster motor and cognitive dysfunction progression. However, there are limited studies on possible structural brain changes underpinning this disorder.
methodsDiffusion magnetic resonance imaging (DMRI) was used to assess whether microstructural abnormalities in the brain of 23 RBD positive PD are detectable compared to 31 RBD negative PD. DMRI scans were analyzed without a prior hypothesis. Diffusion MRI connectometry was used to carry out group analysis between age and gender matched PD patients with and without RBD. Diffusion MRI connectometry is based on spin distribution function (SDF) which quantifies the density of diffusing water and is more sensitive to psychological differences between groups.
resultsPatients with RBD positive showed microstructural white matter changes in the left and right cingulum, inferior front occipital fasciculus (IFOF), bilateral corticospinal tracts (CST), and middle cerebellar peduncles (MCPs), compared to patients without RBD.
conclusionsWhite matter alterations in the cingulum, IFOF regions, and corpus callosum might explain faster cognitive deterioration in PD patients with RBD, in terms of visual recognition and visuospatial dysfunction and executive function. Disturbed brain structural tissue markers in CST in PD + RBD patients, could be justified in the light of faster motor progression in these patients.
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