SynthesisDrugs in R&D2017
A Guide to Medications Inducing Salivary Gland Dysfunction, Xerostomia, and Subjective Sialorrhea: A Systematic Review Sponsored by the World Workshop on Oral Medicine VI.
Synthesis in Drugs in R&D, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05247008 (Effectiveness of Thyme Honey in Management of Xerostomia in Geriatric Patients With ESRD), which is not on this map. Cited by 138 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness of Thyme Honey in Management of Xerostomia in Geriatric Patients With ESRD: Longitudinal Prospective Clinical Biochemical Study
Who cites it
138 citing papers in PubMed, 8 syntheses or guidelines pooled it, 331 citations in OpenAlex.
- Prevalence of xerostomia and hyposalivation in older adults: a systematic review and meta-analysis.BMC oral health · 2026Pooled it
- Psychological disorders and their influence on the development of periodontal disease in adolescents. A systematic review.Medicina oral, patologia oral y cirugia bucal · 2026Pooled it
- MASCC/ISOO Clinical Practice Statement: Management of salivary gland hypofunction and xerostomia in cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Guideline
- MASCC/ISOO Clinical Practice Statement: Management of oral complications of targeted therapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Guideline
- MASCC/ISOO Clinical Practice Statement: Clinical assessment of salivary gland hypofunction and xerostomia in cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Guideline
- Autistic individuals have worse oral status than neurotypical controls: a systematic review and meta-analysis of observational studies.Clinical oral investigations · 2024Pooled it
- Association between medication-induced xerostomia and orofacial pain: a systematic review.Quintessence international (Berlin, Germany : 1985) · 2023Pooled it
- The effect of hematopoietic stem cell transplantation on patient-reported subjective oral dryness: a systematic review focusing on prevalence, severity and distress.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Pooled it
- Low-level laser and transcutaneous electrical nerve stimulation on salivary glands impact type 2 diabetes mellitus oral microbiome: an interim analysis of a randomized trial.Lasers in medical science · 2025Trial
- Effectiveness of HAPA-based oral hygiene instruction in patients over 65 years of age: a randomized controlled trial.BMC oral health · 2025Trial
- Xerogenic medications and clinical markers of salivary hypofunction.Clinical oral investigations · 2026Article
- The Role of Saliva in Swallowing: A Systematic Review.Dysphagia · 2026Review
- Pharmacists' role in recognising medication-related oral health risks in aged care: a qualitative study of pharmacists' and dentists' perspectives.International journal of clinical pharmacy · 2026Article
- Detection of Signals for Smell and Taste Disorders Associated with Z-drugs: A Disproportionality Analysis of the FAERS Database.Oral health & preventive dentistry · 2026Article
- Associations between oral health-related and overall quality of life in patients receiving oncological palliative care: a single-center cross-sectional study in Southern Chile.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Impact of TCAs and Gabapentin on Saliva and BMI in Adults With Xerostomia.Journal of oral rehabilitation · 2026Article
- From Traditional Inspection to Quantitative Imaging: Tongue and Facial Color Features for Automated Machine Learning-Driven Depression and Schizophrenia Classification.Behavioral sciences (Basel, Switzerland) · 2026Article
- Photobiomodulation for salivary gland dysfunction: aligning clinical expectations with etiology-dependent treatment responsiveness.Lasers in medical science · 2026Review
- Patterns and Safety-Related Aspects of Antidepressant and Anxiolytic Use Among Healthcare Students and University Staff at a Brazilian Public University: A Cross-Sectional Study.Pharmacy (Basel, Switzerland) · 2026Article
- Stimulated whole salivary flow is correlated with xerostomia severity and unstimulated whole salivary flow in adults with xerostomia taking anticholinergic medications.Archives of oral biology · 2026Article
78 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 14 institutions in 10 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMedication-induced salivary gland dysfunction (MISGD), xerostomia (sensation of oral dryness), and subjective sialorrhea cause significant morbidity and impair quality of life. However, no evidence-based lists of the medications that cause these disorders exist.
objectiveOur objective was to compile a list of medications affecting salivary gland function and inducing xerostomia or subjective sialorrhea. DATA SOURCES: Electronic databases were searched for relevant articles published until June 2013. Of 3867 screened records, 269 had an acceptable degree of relevance, quality of methodology, and strength of evidence. We found 56 chemical substances with a higher level of evidence and 50 with a moderate level of evidence of causing the above-mentioned disorders. At the first level of the Anatomical Therapeutic Chemical (ATC) classification system, 9 of 14 anatomical groups were represented, mainly the alimentary, cardiovascular, genitourinary, nervous, and respiratory systems. Management strategies include substitution or discontinuation of medications whenever possible, oral or systemic therapy with sialogogues, administration of saliva substitutes, and use of electro-stimulating devices. LIMITATIONS: While xerostomia was a commonly reported outcome, objectively measured salivary flow rate was rarely reported. Moreover, xerostomia was mostly assessed as an adverse effect rather than the primary outcome of medication use. This study may not include some medications that could cause xerostomia when administered in conjunction with others or for which xerostomia as an adverse reaction has not been reported in the literature or was not detected in our search.
conclusionsWe compiled a comprehensive list of medications with documented effects on salivary gland function or symptoms that may assist practitioners in assessing patients who complain of dry mouth while taking medications. The list may also prove useful in helping practitioners anticipate adverse effects and consider alternative medications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.