Evidence map›Paper›PMID 27853930›Full record

SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2017

A systematic review of oral herpetic viral infections in cancer patients: commonly used outcome measures and interventions.

Sharon Elad, Vinisha Ranna, Anura Ariyawardana, Maria Elvira Pizzigatti Correa, Vanessa Tilly, Raj G Nair, Tanya Rouleau, Richard M Logan, Andres Pinto, Veronica Charette and 3 more

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Guideline
  2. Characteristics of Acyclovir-Resistant Herpes Simplex Virus Infection in Hematological Patients.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2026
    Article
  3. Article
  4. Guide for health professionals addressing oral care for individuals in oncological treatment based on scientific evidence.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 5 countries.

Sharon EladDepartment of Oral Medicine, Eastman Institute for Oral Health, University of Rochester Medical Center, Rochester, NY, 14620, USA. selad@urmc.rochester.edu.
Vinisha RannaDepartment of Oral Medicine, Eastman Institute for Oral Health, University of Rochester Medical Center, Rochester, NY, 14620, USA.
Anura AriyawardanaCollege of Medicine and Dentistry, James Cook University, Cairns, Australia.
Maria Elvira Pizzigatti CorreaOral Medicine Ambulatory, Hematology and Hemotherapy Center, University of Campinas, Campinas, Brazil.
Vanessa TillyDental Oncology Service, Instituto do Câncer do Estado de São Paulo, Faculdade de Medicina da Universidade de São Paulo, FFMUSP, São Paulo, Brazil.
Raj G NairOral Medicine/Oral Oncology, Oral Pathology and Human Diseases, Griffith University and Menzies Health Institute Queensland, Gold Coast, Australia.
Tanya RouleauDental Oncology Program, Health Sciences North, North East Cancer Center, Sudbury, ON, Canada.
Richard M LoganSchool of Dentistry, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, Australia.
Andres PintoOral and Maxillofacial Medicine and Diagnostic Sciences, University Hospitals Case Medical Center, Cleveland, OH, USA.
Veronica CharetteDental Oncology Program, Health Sciences North, North East Cancer Center, Sudbury, ON, Canada.
Debbie P SaundersDental Oncology Program, Health Sciences North, North East Cancer Center, Sudbury, ON, Canada.
Siri Beier JensenDepartment of Dentistry and Oral Health, Faculty of Health, Aarhus University, Aarhus C, Denmark.
Viral Infections Section, Oral Care Study Group, Multinational Association of Supportive Care in Cancer (MASCC)/International Society of Oral Oncology (ISOO)
Health Sciences North · CAUniversity of Rochester Medical Center · USGold Coast Hospital · AUGriffith University · AUInstituto do Câncer do Estado de São Paulo · BRUniversidade Estadual de Campinas (UNICAMP) · BRUniversity Hospitals Case Medical Center · USUniversity of Adelaide · AUUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo review the literature for outcome measures for oral viral infections in cancer patients. A secondary aim was to update the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO) clinical practice guidelines for the management of oral viral infections in cancer patients.

methodsDatabases were searched for articles published in the English language, 1981-2013. Studies that met the eligibility criteria were reviewed systematically. The data about the outcome measures were classified according to the aim of the study: prevention, treatment, or non-interventional. The results of interventional studies were compared to the 2010 MASCC/ISOO publication.

resultsMultiple clinical and laboratory tests were used to measure oral viral infections, with great variability between studies. Most of the studies were about Herpes Simplex Virus (HSV). The outcome measure that was most commonly used was the presence of HSV infection diagnosed based on a combination of suggestive clinical presentation with a positive laboratory result. HSV culture was the most commonly reported laboratory outcome measure. Acyclovir and valacyclovir were consistently reported to be efficacious in the management of oral herpetic infections. No new data on the quality of life and economic aspects was found.

conclusionsConsidering the variability in outcome measures reported to assess oral herpetic infections the researcher should select carefully the appropriate measures based on the objective of the study. Acyclovir and valacyclovir are effective in the management of oral herpetic infections in patients receiving treatment for cancer. Studies on newer anti-viral drugs may be useful to address the issue of anti-viral resistance.

Indexed as

Antiviral AgentsFemaleHumansMouth DiseasesNeoplasmsOutcome Assessment, Health CareQuality of LifeAntiviral AgentsCancerEfficacy of interventionHerpes virusHSVOral viral infectionOutcome measures

Identifiers

PMID27853930
OpenAlexW2555627672

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.