Evidence map›Paper›PMID 27853926›Full record

Trial reportJournal of neural transmission (Vienna, Austria : 1996)2017

Transcranial direct current stimulation improves clinical symptoms in adolescents with attention deficit hyperactivity disorder.

Cornelia Soff, Anna Sotnikova, Hanna Christiansen, Katja Becker, Michael Siniatchkin

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Journal of neural transmission (Vienna, Austria : 1996), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04964427 (The Effects of Methylphenidate), which is not on this map. Cited by 53 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 14 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04964427 nacompletednot on this mapstarted 2021, after this paper: background citation

The Effects of Methylphenidate (MPH) and Non-invasive Brain Stimulation (tDCS) on Inhibitory Control Children With Attention-Deficit/Hyperactivity Disorder (ADHD)

TypeinterventionalSponsorBambino Gesù Hospital and Research InstituteRan2021 to 2022Enrolled26ConditionsAttention Deficit Hyperactivity DisorderArmsMethylphenidate, anodal tDCS, sham tDCS
3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 14 syntheses or guidelines pooled it.

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  16. Multisession tDCS combined with intrastimulation training improves emotion recognition in adolescents with autism spectrum disorder.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Cornelia SoffDepartment for Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Philipps-University, Marburg, Germany.
Anna SotnikovaDepartment for Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Philipps-University, Marburg, Germany.
Hanna ChristiansenInstitute of Clinical Psychology, Philipps-University, Marburg, Germany.
Katja BeckerDepartment for Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Philipps-University, Marburg, Germany.
Michael SiniatchkinInstitute of Medical Psychology and Medical Sociology, Christian Albrecht University, Preußerstraße 1-9, 24105, Kiel, Germany. siniatchkin@med-psych.uni-kiel.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anodal transcranial direct current stimulation (tDCS) of the prefrontal cortex has repeatedly been shown to improve working memory. As patients with attention deficit hyperactivity disorder (ADHD) are characterized by both underactivation of the prefrontal cortex and deficits in working memory that correlate with clinical symptoms, it is hypothesized that the modulation of prefrontal activity with tDCS in patients with ADHD increases performance in working memory and reduces symptoms of ADHD. To test this hypothesis, fifteen adolescents with ADHD (12-16 years old, three girls and 12 boys) were treated according to the randomized, double-blinded, sham-controlled, crossover design with either 1 mA anodal tDCS over the left dorsolateral prefrontal cortex or with the sham protocol 5 days each with a 2 weeks pause between these conditions. Anodal tDCS caused a significant reduction in clinical symptoms of inattention and impulsivity in adolescents with ADHD compared to sham stimulation. The clinical effects were supported by a significant reduction in inattention and hyperactivity in a standardized working memory test (QbTest). The described effects were more pronounced 7 days after the end of stimulation, a fact which emphasizes the long-lasting clinical and neuropsychological changes after tDCS. This study provides the first evidence that tDCS may reduce symptoms of ADHD and improve neuropsychological functioning in adolescents and points on the potential of tDCS as a form of treatment for ADHD.

Indexed as

Transcranial Direct Current StimulationAdolescentAttentionAttention Deficit Disorder with HyperactivityChildCross-Over StudiesDouble-Blind MethodFemaleHumansImpulsive BehaviorMaleMemory, Short-TermNeuropsychological TestsPrefrontal CortexTreatment OutcomeADHDTranscranial direct current stimulationWorking memory

Identifiers

PMID27853926

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.