Evidence map›Paper›PMID 27853898›Full record

Observational studyDigestive diseases and sciences2017

Rate and Predictors of Mucosal Healing in Ulcerative Colitis Treated with Thiopurines: Results of a Multicentric Cohort Study.

Caroline Prieux-Klotz, Stéphane Nahon, Aurelien Amiot, Leila Sinayoko, Carole Galéano-Cassaz, Stanislas Chaussade, Romain Coriat, Pierre Lahmek, Vered Abitbol

Abstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Digestive diseases and sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Caroline Prieux-KlotzDivision of Gastroenterology, Department of Gastroenterology, Cochin Hospital AP-HP, 27, rue du Faubourg Saint Jacques PARIS, 75014, Paris, France. prieuxcaroline@gmail.com.ORCID 0000-0001-8749-651X
Stéphane NahonDivision of Gastroenterology, GHI Le Raincy-Montfermeil, Montfermeil, France.
Aurelien AmiotDepartment of Gastroenterology, Henri Mondor Hospital, APHP, EC2M3-EA75-73, Paris Est-Créteil (UPEC) Val de Marne University, Creteil, France.
Leila SinayokoDivision of Gastroenterology, Begin Military Hospital, Saint-Mandé, France.
Carole Galéano-CassazDivision of Gastroenterology, Val de Grace Military Hospital, Paris, France.
Stanislas ChaussadeDivision of Gastroenterology, Department of Gastroenterology, Cochin Hospital AP-HP, 27, rue du Faubourg Saint Jacques PARIS, 75014, Paris, France.
Romain CoriatDivision of Gastroenterology, Department of Gastroenterology, Cochin Hospital AP-HP, 27, rue du Faubourg Saint Jacques PARIS, 75014, Paris, France.
Pierre LahmekEmile Roux Hospital AP-HP, Limeil-Brevannes, France.
Vered AbitbolDivision of Gastroenterology, Department of Gastroenterology, Cochin Hospital AP-HP, 27, rue du Faubourg Saint Jacques PARIS, 75014, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsMucosal healing (MH) with thiopurines has been poorly investigated in ulcerative colitis (UC). We aimed to assess MH rate in UC patients treated with thiopurine monotherapy. PATIENTS AND

methodsWe retrospectively collected all UC patients treated with thiopurines more than 6 months who have undergone colonoscopy at baseline and after at least 6 months of treatment. Patients were recruited from January 2005 to May 2015 through a personal database and/or standardized hospital inpatient diagnostic dataset. Patients were excluded in case of any use of other immunomodulator or biological agent. MH was defined as a Mayo endoscopic subscore ≤1 and UCEIS ≤ 2. Histological healing (HH) was defined by the absence of epithelial polynuclear infiltrate, cryptic abscesses, or ulcerations.

resultsEighty patients (31 women, median age 43 [IQR 32-58]) were included. Median disease duration was 10.5 [6-16] years. At baseline, median full Mayo score, endoscopic subscore, and UCEIS were 8 [6.8-10], 3 [2-3], and 5 [3-6], respectively. MH was first assessed after a mean follow-up of 38 ± 31 months. Median full Mayo score, endoscopic subscore, and UCEIS decreased to 3.5 [1-6], 2 [0-2.2], and 2 [0-4], respectively. MH was achieved in 43.7%, HH in 38%. In multivariate analysis, predictors of MH were thiopurine exposure duration ≥2 years [odds ratio (OR) 2.9, CI 95% (1.1-7.6), p = 0.03] and a prior acute severe colitis [OR 5.9, CI 95% (1.1-32), p = 0.04]. Factors associated with MH during treatment were partial Mayo score ≤2 (NPV = 100%), BMI ≥ 25 kg/m

conclusionsIn UC, thiopurine monotherapy is associated with MH in 43.7% and HH in 38%.

Indexed as

AdultAzathioprineCohort StudiesColitis, UlcerativeColonoscopyFemaleHumansImmunosuppressive AgentsIntestinal MucosaMaleMercaptopurineMiddle AgedMultivariate AnalysisOdds RatioRetrospective StudiesSeverity of Illness IndexAzathioprineImmunosuppressive AgentsMercaptopurineAzathioprineHistological healingMayo scoreMercaptopurineMucosal healingThiopurineUCEISUlcerative colitis

Identifiers

PMID27853898

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.