Evidence map›Paper›PMID 27853874›Full record

ArticleInternational journal of biometeorology2017

Comparative expression profile of NOD1/2 and certain acute inflammatory cytokines in thermal-stressed cell culture model of native and crossbred cattle.

V Bhanuprakash, Umesh Singh, Gyanendra Singh Sengar, T V Raja, Basavraj Sajjanar, Rani Alex, Sushil Kumar, R R Alyethodi, Ashish Kumar, Ankur Sharma and 3 more

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in International journal of biometeorology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

V BhanuprakashMolecular Genetics Laboratory, ICAR-Central Institute for Research on Cattle, Meerut, Uttar Pradesh, 250001, India. bhanupvhn24@gmail.com.
Umesh SinghMolecular Genetics Laboratory, ICAR-Central Institute for Research on Cattle, Meerut, Uttar Pradesh, 250001, India.
Gyanendra Singh SengarMolecular Genetics Laboratory, ICAR-Central Institute for Research on Cattle, Meerut, Uttar Pradesh, 250001, India.
T V RajaMolecular Genetics Laboratory, ICAR-Central Institute for Research on Cattle, Meerut, Uttar Pradesh, 250001, India.
Basavraj SajjanarSchool of Abiotic Stress Management, ICAR-National Institute of Abiotic Stress Management, Baramati, India.
Rani AlexMolecular Genetics Laboratory, ICAR-Central Institute for Research on Cattle, Meerut, Uttar Pradesh, 250001, India.
Sushil KumarMolecular Genetics Laboratory, ICAR-Central Institute for Research on Cattle, Meerut, Uttar Pradesh, 250001, India.
R R AlyethodiMolecular Genetics Laboratory, ICAR-Central Institute for Research on Cattle, Meerut, Uttar Pradesh, 250001, India.
Ashish KumarMolecular Genetics Laboratory, ICAR-Central Institute for Research on Cattle, Meerut, Uttar Pradesh, 250001, India.
Ankur SharmaMolecular Genetics Laboratory, ICAR-Central Institute for Research on Cattle, Meerut, Uttar Pradesh, 250001, India.
Suresh KumarMolecular Genetics Laboratory, ICAR-Central Institute for Research on Cattle, Meerut, Uttar Pradesh, 250001, India.
Bharat BhusanDivision of Animal Genetics and Breeding, ICAR-Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh, 243122, India.
Rajib DebMolecular Genetics Laboratory, ICAR-Central Institute for Research on Cattle, Meerut, Uttar Pradesh, 250001, India. drrajibdeb@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thermotolerance depends mainly on the health and immune status of the animals. The variation in the immune status of the animals may alter the level of tolerance of animals exposed to heat or cold stress. The present study was conducted to investigate the expression profile of two important nucleotide binding and oligomerization domain receptors (NLRs) (NOD1 and NOD2) and their central signalling molecule RIP2 gene during in vitro thermal-stressed bovine peripheral blood mononuclear cells (PBMCs) of native (Sahiwal) and crossbred (Sahiwal X HF) cattle. We also examined the differential expression profile of certain acute inflammatory cytokines in in vitro thermal-stressed PBMC culture among native and its crossbred counterparts. Results revealed that the expression profile of NOD1/2 positively correlates with the thermal stress, signalling molecule and cytokines. Present findings also highlighted that the expression patterns during thermal stress were comparatively superior among indigenous compared to crossbred cattle which may add references regarding the better immune adaptability of Zebu cattle.

Indexed as

AnimalsCattleCells, CulturedCold-Shock ResponseCytokinesFemaleGene ExpressionHeat-Shock ResponseLeukocytes, MononuclearNod1 Signaling Adaptor ProteinNod2 Signaling Adaptor ProteinReceptor-Interacting Protein Serine-Threonine Kinase 2RNA, MessengerSpecies SpecificityCytokinesNod1 Signaling Adaptor ProteinNod2 Signaling Adaptor ProteinReceptor-Interacting Protein Serine-Threonine Kinase 2RNA, MessengerCattleIL-1IL-6IL-8NOD1NOD2RIP2Thermal stressTNFα

Identifiers

PMID27853874

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.