Evidence map›Paper›PMID 27853869›Full record

ArticleJournal of cancer research and clinical oncology2017

Survival of de novo stage IV breast cancer patients over three decades.

Dieter Hölzel, Renate Eckel, Ingo Bauerfeind, Bernd Baier, Thomas Beck, Michael Braun, Johannes Ettl, Ulrich Hamann, Nadia Harbeck, Marion Kiechle and 4 more

Open access · greenAbstract read
In one paragraph

Article in Journal of cancer research and clinical oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Article
  3. Breast Reconstruction in De Novo Metastatic Breast Cancer: A Systematic Review.Plastic and reconstructive surgery. Global open · 2025
    Article
  4. Observational
  5. Article
  6. Article
  7. Article
  8. Survival in male breast cancer over the past 3 decades.Journal of the National Cancer Institute · 2023
    Article
  9. Review
  10. EClinicalMedicine · 2022
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Prognostic Value of Site-Specific Metastases and Surgery in De Novo Stage IV Triple-Negative Breast Cancer: A Population-Based Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2020
    Article
  16. Article
  17. Article
  18. Article
  19. Does adjuvant therapy reduce postmetastatic survival?Annals of oncology : official journal of the European Society for Medical Oncology · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 1 country.

Dieter HölzelMunich Cancer Registry (MCR) of the Munich Tumour Centre (TZM), Institute for Medical Information Processing, Biometry and Epidemiology (IBE), University Hospital of Munich, Ludwig-Maximilians-University (LMU), Tumorregister München, Klinikum Großhadern/IBE, 81377, Munich, Germany.
Renate EckelMunich Cancer Registry (MCR) of the Munich Tumour Centre (TZM), Institute for Medical Information Processing, Biometry and Epidemiology (IBE), University Hospital of Munich, Ludwig-Maximilians-University (LMU), Tumorregister München, Klinikum Großhadern/IBE, 81377, Munich, Germany.
Ingo BauerfeindHead of the Breast Cancer Project Group of the Munich Tumour Centre (TZM) and of Department of Obstetrics and Gynaecology, Klinikum Landshut, Landshut, Germany.
Bernd BaierDepartment of Obstetrics and Gynaecology, Klinikum Dachau, Dachau, Germany.
Thomas BeckDepartment of Obstetrics and Gynaecology, Klinikum Rosenheim, Rosenheim, Germany.
Michael BraunDepartment of Gynaecology, Rotkreuzklinikum, Munich, Germany.
Johannes EttlDepartment of Obstetrics and Gynaecology, Klinikum rechts der Isar, Technical University of Munich (TUM), Munich, Germany.
Ulrich HamannDepartment of Gynaecology, Rotkreuzklinikum, Munich, Germany.
Nadia HarbeckBreast Center, Department of Obstetrics and Gynaecology, University Hospital of Munich, Ludwig-Maximilians-University (LMU), Munich, Germany.
Marion KiechleDepartment of Obstetrics and Gynaecology, Klinikum rechts der Isar, Technical University of Munich (TUM), Munich, Germany.
Sven MahnerDepartment of Obstetrics and Gynaecology, University Hospital of Munich, Ludwig-Maximilians-University (LMU), Munich, Germany.
Christian SchindlbeckDepartment of Obstetrics and Gynaecology, Klinikum Traunstein, Traunstein, Germany.
Johann de WaalDepartment of Obstetrics and Gynaecology, Klinikum Dachau, Dachau, Germany.
Jutta EngelMunich Cancer Registry (MCR) of the Munich Tumour Centre (TZM), Institute for Medical Information Processing, Biometry and Epidemiology (IBE), University Hospital of Munich, Ludwig-Maximilians-University (LMU), Tumorregister München, Klinikum Großhadern/IBE, 81377, Munich, Germany. engel@ibe.med.uni-muenchen.de.
Ludwig-Maximilians-Universität München · DEHelios Amper-Klinikum Dachau · DEKlinikum rechts der Isar · DERotkreuzklinikum München · DEMünchen Klinik · DERosenheim Technical University of Applied Sciences · DEUniversity of Applied Sciences Landshut · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDe novo stage IV breast cancer patients (BC

methodsBC

resultsBetween 1978 and 2013, 88,759 patients were diagnosed with 92,807 cases of invasive and non-invasive BC. Of these patients, 4756 patients had distant metastases (MET) at diagnosis. The 5-year survival rate improved from 17.4 to 24.7%, while the pattern of metastases did not change. Improved staging diagnostics, a screening programme and primary systemic therapy changed the composition of prognostic strata. Patients with a similar composition as the 1978-1987 cohort exhibited a median survival difference of 13 months; however, neither univariate nor multivariate analysis showed a survival effect for the four periods as a surrogate indicator for changing treatments. HER2+ patients have with 27.6 months a slightly longer survival than all other BC

conclusionsSurvival of de novo BC

Indexed as

PrognosisAdultAgedAged, 80 and overBreast NeoplasmsCombined Modality TherapyDisease-Free SurvivalFemaleHumansKaplan-Meier EstimateMiddle AgedNeoplasm Recurrence, LocalNeoplasm StagingRetrospective StudiesBreast cancerMetastasis organsStage IVSurvivalTrends

Identifiers

PMID27853869
PMCPMC11819153
OpenAlexW2553863256

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.