ArticlePlant cell reports2017
Increasing the synthesis of bioactive abietane diterpenes in Salvia sclarea hairy roots by elicited transcriptional reprogramming.
Article in Plant cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 37 citations in OpenAlex.
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- Plant hairy roots for the production of extracellular vesicles with antitumor bioactivity.Communications biology · 2022Article
- Biotic Elicitors in Adventitious and Hairy Root Cultures: A Review from 2010 to 2022.Molecules (Basel, Switzerland) · 2022Review
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- De Novo Transcriptome Analysis Reveals Putative Genes Involved in Anthraquinone Biosynthesis inGenes · 2022Article
- Abietane Diterpenoids from the Hairy Roots ofMolecules (Basel, Switzerland) · 2021Article
- New Insight into Justicidin B Pathway and Production inInternational journal of molecular sciences · 2021Article
- Boosting the Synthesis of Pharmaceutically Active Abietane Diterpenes inFrontiers in plant science · 2020Article
- Elicitation: A biotechnological tool for enhanced production of secondary metabolites in hairy root cultures.Engineering in life sciences · 2019Review
- Comparative transcriptomic analysis reveal the regulation mechanism underlying MeJA-induced accumulation of alkaloids in Dendrobium officinale.Journal of plant research · 2019Article
- Coactivation of MEP-biosynthetic genes and accumulation of abietane diterpenes in Salvia sclarea by heterologous expression of WRKY and MYC2 transcription factors.Scientific reports · 2018Article
- Metabolic Profiling of Dendrobium officinale in Response to Precursors and Methyl Jasmonate.International journal of molecular sciences · 2018Article
Corrections and comments
- Erratum issued
- Erratum issuedCorrection to: Increasing the synthesis of bioactive abietane diterpenes in Salvia sclarea hairy roots by elicited transcriptional reprogramming.2018 · Mariaevelina, A [corrected to Alfieri, M]
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
key messageTranscriptional activation of genes belonging to the plastidial MEP-derived isoprenoid pathway by elicitation with methyl jasmonate and coronatine enhanced the content of bioactive abietane diterpenes in Salvia sclarea hairy roots. We have shown that aethiopinone, an abietane diterpene synthesized in Salvia sclarea roots is cytotoxic and induces apoptosis in human melanoma cells. To develop a production platform for this compound and other abietane diterpenes, hairy root technology was combined with the elicitation of methyl jasmonate (MeJA) or the phytotoxin coronatine (Cor). Both MeJA and Cor induced a significant accumulation of aethiopinone, but prolonged exposure to MeJA irremediably caused inhibition of hairy root growth, which was unaffected by Cor treatment. Considering together the fold increase in aethiopinone content and the final hairy root biomass, the best combination was a Cor treatment for 28 days, which allowed to obtain up to 105.34 ± 2.30 mg L
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