Evidence map›Paper›PMID 27853629›Full record

ReviewAmerican journal of stem cells2016

Current progress of human trials using stem cell therapy as a treatment for diabetes mellitus.

Shuk Kei Cheng, Elisse Y Park, Andjela Pehar, Alexandra C Rooney, G Ian Gallicano

Abstract readReview
In one paragraph

Review in American journal of stem cells, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
9.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Current Status of Stem Cell Treatment for Type I Diabetes Mellitus.Tissue engineering and regenerative medicine · 2018
    Review
  5. The combined effect ofFEBS open bio · 2018
    Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Shuk Kei ChengGeorgetown University School of Medicine, Georgetown University Medical Center Washington DC, USA.
Elisse Y ParkGeorgetown University School of Medicine, Georgetown University Medical Center Washington DC, USA.
Andjela PeharGeorgetown University School of Medicine, Georgetown University Medical Center Washington DC, USA.
Alexandra C RooneyGeorgetown University School of Medicine, Georgetown University Medical Center Washington DC, USA.
G Ian GallicanoGeorgetown University School of Medicine, Georgetown University Medical CenterWashington DC, USA; Department of Biochemistry and Molecular and Cellular Biology, Georgetown University Medical CenterWashington DC, USA.
Georgetown University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes mellitus affects millions of people worldwide, and is associated with serious complications that affect nearly all body systems. Because of the severity of this global health concern, there is a great deal of research being performed on alternative treatments and possible cures. Previous treatments for diabetes have included exogenous insulin injection and pancreatic islet transplantations. These treatment methods have several limitations; thus, the use of stem cells in treating diabetes is currently a significant area of research. This review outlines current research on stem cell therapy for diabetes mellitus. Numerous studies have been performed on animals using various types of stem cells, including mesenchymal stem cells and embryonic stem cells. Moreover, results and limitations of animal studies have been confirmed in various clinical trials. Overall, stem cell treatment shows prospective advantages over insulin injections and other current treatment options, and ongoing clinical trials suggest that this therapy may be a viable treatment option for diabetics in the near future.

Indexed as

adult stem cellsDiabetesembryonic stem cellshuman trialsIPS cellsspermatogonial stem cells

Identifiers

PMID27853629
PMCPMC5107652
OpenAlexW2555273021

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.