Evidence map›Paper›PMID 27853451›Full record

ArticleFrontiers in microbiology2016

High Protective Efficacy of Probiotics and Rice Bran against Human Norovirus Infection and Diarrhea in Gnotobiotic Pigs.

Shaohua Lei, Ashwin Ramesh, Erica Twitchell, Ke Wen, Tammy Bui, Mariah Weiss, Xingdong Yang, Jacob Kocher, Guohua Li, Ernawati Giri-Rachman and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 67 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 3 countries.

Shaohua LeiDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg VA, USA.
Ashwin RameshDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg VA, USA.
Erica TwitchellDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg VA, USA.
Ke WenDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg VA, USA.
Tammy BuiDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg VA, USA.
Mariah WeissDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg VA, USA.
Xingdong YangDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg VA, USA.
Jacob KocherDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg VA, USA.
Guohua LiDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg VA, USA.
Ernawati Giri-RachmanDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, BlacksburgVA, USA; School of Life Science and Technology, Institut Teknologi, BandungWest Java, Indonesia.
Nguyen Van TrangNational Institute of Hygiene and Epidemiology Hanoi, Vietnam.
Xi JiangDivision of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati OH, USA.
Elizabeth P RyanDepartment of Environmental and Radiological Health Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins CO, USA.
Lijuan YuanDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg VA, USA.
Virginia–Maryland College of Veterinary Medicine · USVirginia Tech · USBandung Institute of Technology · IDCincinnati Children's Hospital Medical Center · USColorado State University · USNational Institute Of Hygiene And Epidemiology · VN

Funding

Novel vaccine against NorovirusR01AI089634 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI JIANG, XI · 2010 to 2014
$4.7M
NIAID NIH HHS R01 AI089634
6 · The paper itself

Abstract

Probiotics have been recognized as vaccine adjuvants and therapeutic agents to treat acute gastroenteritis in children. We previously showed that rice bran (RB) reduced human rotavirus diarrhea in gnotobiotic pigs. Human noroviruses (HuNoVs) are the major pathogens causing non-bacterial acute gastroenteritis worldwide. In this study,

Indexed as

diarrheagnotobiotic pigshuman norovirusprobioticsrice bran

Identifiers

PMID27853451
PMCPMC5090003
OpenAlexW2548394883

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.