ReviewFrontiers in physiology2016
Wound Healing Problems in the Mouth.
Review in Frontiers in physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
109 citing papers in PubMed, 1 synthesis or guideline pooled it, 221 citations in OpenAlex.
- Efficacy of photobiomodulation on accelerating bone healing after tooth extraction: a systematic review.Lasers in medical science · 2019Pooled it
- Effect of photobiomodulation therapy on wound healing and post-extraction pain management of primary molars: a randomized controlled clinical trial.BMC oral health · 2026Trial
- Effect of mucosal fenestration drainage on postoperative complications following surgical extraction of mandibular third molars: a randomized controlled clinical trial.BMC oral health · 2026Trial
- Trial
- Simple versus cross-mattress sutures for nondisplaced flaps of the maxillary molar region: a randomized controlled trial.BMC oral health · 2022Trial
- Evaluating Soft Tissue Healing after Implant Placement Using Two Different Mouthwashes (Myrrh and Chlorhexidine Gluconate): A Randomized Control Trial.Medicina (Kaunas, Lithuania) · 2022Trial
- Effect of lingual-based flap design on postoperative pain of impacted mandibular third molar surgery: Split-mouth randomized clinical trial.Medicina oral, patologia oral y cirugia bucal · 2020Trial
- Effectiveness of Low-Level Laser Therapy with a 915 Nm Wavelength Diode Laser on the Healing of Intraoral Mucosal Wound: An Animal Study and a Double-Blind Randomized Clinical Trial.Medicina (Kaunas, Lithuania) · 2019Trial
- Histological effects of chitosan, chitosan-carried hyaluronic acid, and photobiomodulation on palatal wound healing in rats: an in vivo study.Clinical oral investigations · 2026Article
- Modulating the periodontal wound microenvironment through oxygen therapy: a narrative review on the biological basis, clinical applications and future perspectives.The Saudi dental journal · 2026Review
- Dehydrocorydaline Accelerates Palatal Wound Healing in Mice Through Suppression of the p38 MAPK/CCL2 Axis and Macrophage Chemotaxis: A Preliminary Study.Biomedicines · 2026Article
- Protective and Healing Effects of Zinc L-Carnosine on the Oral Mucosa: A Systematic Review and Meta-Analysis.Dentistry journal · 2026Review
- Effect of Probiotic Limosilactobacillus reuteri and Hyaluronic Acid Gel Combination Therapy on Neutrophil Response, Neovascularization, and Reepithelialization in the Wound-Healing Process Following Tooth Extraction: An In Vivo Study.European journal of dentistry · 2026Article
- Clinical applications of chlorhexidine in oral wound healing: Scoping review of current evidence and research gaps.Medicina oral, patologia oral y cirugia bucal · 2026Article
- Hyaluronic Acid-Based Gels and Biomaterial Systems for Oral Wound Healing: Design and Clinical Translation.Gels (Basel, Switzerland) · 2026Review
- Alpha-ketoglutarate restores oral epithelial homeostasis via FOXM1-mediated cell cycle regulation.Science China. Life sciences · 2026Article
- Harnessing the Therapeutic Potential of Extracellular Vesicles for Oral Wound Healing.Bioengineering (Basel, Switzerland) · 2026Review
- Suppression of distal-less homeobox 3 increased alveolar bone mass in mouse tooth socket by targeting thrombospondin 1.Journal of dental sciences · 2026Article
- Innovative biomaterials in promoting intraoral wound healing: Mechanisms, applications, and challenges.Materials today. Bio · 2025Review
- Association between bone turnover markers and alveolar socket healing rate: A cross-sectional study.Oral and maxillofacial surgery · 2025Article
49 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wound healing is a primary survival mechanism that is largely taken for granted. The literature includes relatively little information about disturbed wound healing, and there is no acceptable classification describing wound healing process in the oral region. Wound healing comprises a sequence of complex biological processes. All tissues follow an essentially identical pattern to complete the healing process with minimal scar formation. The oral cavity is a remarkable environment in which wound healing occurs in warm oral fluid containing millions of microorganisms. The present review provides a basic overview of the wound healing process and with a discussion of the local and general factors that play roles in achieving efficient would healing. Results of oral cavity wound healing can vary from a clinically healed wound without scar formation and with histologically normal connective tissue under epithelial cells to extreme forms of trismus caused by fibrosis. Many local and general factors affect oral wound healing, and an improved understanding of these factors will help to address issues that lead to poor oral wound healing.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.