Evidence map›Paper›PMID 27853354›Full record

ArticleDrug design, development and therapy2016

Development of novel HER2 inhibitors against gastric cancer derived from flavonoid source of

Tirumalasetty Muni Chandra Babu, Aluru Rammohan, Vijaya Bhaskar Baki, Savita Devi, Duvvuru Gunasekar, Wudayagiri Rajendra

Open access · goldAbstract readComparative Study
In one paragraph

Article in Drug design, development and therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Tirumalasetty Muni Chandra BabuBioinformatics Center, Division of Molecular Biology, Department of Zoology.
Aluru RammohanNatural Products Division, Department of Chemistry, Sri Venkateswara University, Tirupati, Andhra Pradesh.
Vijaya Bhaskar BakiBioinformatics Center, Division of Molecular Biology, Department of Zoology.
Savita DeviPathogen Biology Laboratory, Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad, India.
Duvvuru GunasekarNatural Products Division, Department of Chemistry, Sri Venkateswara University, Tirupati, Andhra Pradesh.
Wudayagiri RajendraBioinformatics Center, Division of Molecular Biology, Department of Zoology.
Sri Venkateswara University · INUniversity of Hyderabad · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Continuous usage of synthetic chemotherapeutic drugs causes adverse effects, which prompted for the development of alternative therapeutics for gastric cancer from natural source. This study was carried out with a specific aim to screen gastroprotective compounds from the fruits of

Indexed as

Molecular Docking SimulationMolecular Dynamics SimulationAntineoplastic Agents, PhytogenicBinding SitesCell Line, TumorCell ProliferationChromatography, GelDose-Response Relationship, DrugDrug DiscoveryErb-b2 Receptor Tyrosine KinasesFlavonoidsFruitG2 Phase Cell Cycle CheckpointsHumansInhibitory Concentration 50Magnetic Resonance SpectroscopyAntineoplastic Agents, PhytogenicERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesFlavonoidsProtein Kinase Inhibitorscell cyclegastric cancermolecular dockingmolecular dynamicspharmacophore

Identifiers

PMID27853354
PMCPMC5104305
OpenAlexW2547761729

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.