ArticleScientific reports2016
Structured plant metabolomics for the simultaneous exploration of multiple factors.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
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- Multi-omics Analysis Reveals the Hormonal Basis of Differential Response to Nighttime Heat Temperature Between Superior and Inferior Rice Grains.Rice (New York, N.Y.) · 2026Article
- Calcium supply promotes seed germination in Tartary buckwheat (Fagopyrum tataricum) by mediating amino acid and lipid metabolism to drive osmotic regulation and antioxidant responses.BMC plant biology · 2026Article
- Metabolic and Microbial Community Profiles of Century-Old Pu-Erh Tea: An Integrative Metabolomic and Microbiomic Analysis.Foods (Basel, Switzerland) · 2026Article
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- Multi-omics analysis reveals the mechanism underlying microbial-driven flavor formation in fermented xuecai (Frontiers in microbiology · 2026Article
- Metabolomic and flavoromic insights into the effects ofFrontiers in nutrition · 2026Article
- AhMTP9-Mediated manganese tolerance mechanisms in peanut: integrated physiological and molecular responses of roots and leaves to Mn stress.BMC plant biology · 2025Article
- The Synergistic Effects of Jasmonic Acid and Arbuscular Mycorrhizal Fungi in Enhancing the Herbicide Resistance of an Invasive WeedMicroorganisms · 2025Article
- Associations of microbial communities with metabolites and enzyme activities in different colors of high-temperature Daqu.World journal of microbiology & biotechnology · 2025Article
- Effect of Storage Time on the Fermentation Quality, Bacterial Community Structure, and Metabolic Profiles of Jinmu Grain Grass Silage.Microorganisms · 2025Article
- Characterization of key astringent compounds and optimization of the fixation process of early tea in Chuanyu region.NPJ science of food · 2025Article
- Preliminary Study on the Geochemical Characterization of Viticis Fructus Cuticular Waxes: From Latitudinal Variation to Origin Authentication.International journal of molecular sciences · 2025Article
- Unveiling the genetic basis of floral scent formation in roses using weighted gene co-expression and protein-protein interaction network analyses.Scientific reports · 2025Article
- Combined Network Pharmacology, Transcriptomics and Metabolomics Strategies Reveal the Mechanism of Action of Lang Chuang Wan to Ameliorate Lupus Nephritis in MRL/lpr Mice.Pharmaceuticals (Basel, Switzerland) · 2025Article
- A Comprehensive Metabolomic Analysis of Volatile and Non-Volatile Compounds inFoods (Basel, Switzerland) · 2025Article
- Integrated transcriptomic and metabolomic analyses reveal critical gene regulatory network in response to drought stress in Dendrobium nobile Lindl.BMC plant biology · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
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Abstract
Multiple factors act simultaneously on plants to establish complex interaction networks involving nutrients, elicitors and metabolites. Metabolomics offers a better understanding of complex biological systems, but evaluating the simultaneous impact of different parameters on metabolic pathways that have many components is a challenging task. We therefore developed a novel approach that combines experimental design, untargeted metabolic profiling based on multiple chromatography systems and ionization modes, and multiblock data analysis, facilitating the systematic analysis of metabolic changes in plants caused by different factors acting at the same time. Using this method, target geraniol compounds produced in transgenic tobacco cell cultures were grouped into clusters based on their response to different factors. We hypothesized that our novel approach may provide more robust data for process optimization in plant cell cultures producing any target secondary metabolite, based on the simultaneous exploration of multiple factors rather than varying one factor each time. The suitability of our approach was verified by confirming several previously reported examples of elicitor-metabolite crosstalk. However, unravelling all factor-metabolite networks remains challenging because it requires the identification of all biochemically significant metabolites in the metabolomics dataset.
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