Evidence map›Paper›PMID 27853260›Full record

ArticleScientific reports2016

The synthetic antimicrobial peptide 19-2.5 attenuates septic cardiomyopathy and prevents down-regulation of SERCA2 in polymicrobial sepsis.

Lukas Martin, Klemens Horst, Fausto Chiazza, Silvia Oggero, Massimo Collino, Klaus Brandenburg, Frank Hildebrand, Gernot Marx, Christoph Thiemermann, Tobias Schuerholz

Abstract read
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Review
  2. Effect of premorbid beta-blockers on cardiac function and clinical outcomes in septic patients: a retrospective study.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lukas MartinDepartment of Intensive Care and Intermediate Care, University Hospital RWTH Aachen, Aachen, Germany.
Klemens HorstDepartment of Orthopaedic Trauma, University Hospital RWTH Aachen, Aachen, Germany.
Fausto ChiazzaDepartment of Drug Science &Technology, University of Turin, Turin, Italy.
Silvia OggeroDepartment of Drug Science &Technology, University of Turin, Turin, Italy.
Massimo CollinoDepartment of Drug Science &Technology, University of Turin, Turin, Italy.
Klaus BrandenburgDivision of Biophysics, Forschungszentrum Borstel, Borstel, Germany.
Frank HildebrandDepartment of Orthopaedic Trauma, University Hospital RWTH Aachen, Aachen, Germany.
Gernot MarxDepartment of Intensive Care and Intermediate Care, University Hospital RWTH Aachen, Aachen, Germany.
Christoph ThiemermannThe William Harvey Research Institute, Barts &The London School of Medicine &Dentistry, Queen Mary University of London, London, UK.
Tobias SchuerholzDepartment of Intensive Care and Intermediate Care, University Hospital RWTH Aachen, Aachen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An impairment of cardiac function is a key feature of the cardiovascular failure associated with sepsis. Although there is some evidence that suppression of sarcoplasmic reticulum Ca

Indexed as

AnimalsAntimicrobial Cationic PeptidesCardiomyopathiesDown-RegulationHumansMiceMyocardial ContractionMyocytes, CardiacNF-kappa BNitric Oxide Synthase Type IIIProto-Oncogene Proteins c-aktSarcoplasmic Reticulum Calcium-Transporting ATPasesSepsisAntimicrobial Cationic PeptidesAtp2a2 protein, mouseNF-kappa BNitric Oxide Synthase Type IIINos3 protein, mouseProto-Oncogene Proteins c-aktSarcoplasmic Reticulum Calcium-Transporting ATPases

Identifiers

PMID27853260
PMCPMC5112529

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.