Evidence map›Paper›PMID 27853162›Full record

ReviewNature reviews. Cardiology2017

Depression and coronary heart disease.

Robert M Carney, Kenneth E Freedland

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Cardiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03953924 (Effects of Transtheoretical Model-based Intervention and Motivational Interviewing on the Management of Depression in Hospitalized Patients With Coronary Heart Disease), which is not on this map. Cited by 316 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
316citing papers in PubMed, 15 pooled it
27.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03953924 nacompletednot on this map

Effects of Transtheoretical Model-based Intervention and Motivational Interviewing on the Management of Depression in Hospitalized Patients With Coronary Heart Disease : A Randomized, Controlled Trial

TypeinterventionalSponsorCentral South UniversityRan2015 to 2015Enrolled110ConditionsCoronary Heart Disease, DepressionArmsTranstheoretical model-based (TTM - based) intervention and motivational interviewing (MI)
3 · Its place in the literature

Who cites it

316 citing papers in PubMed, 15 syntheses or guidelines pooled it, 671 citations in OpenAlex.

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  6. Prevalence of CVD Among Indian Adult Population: Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2025
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  12. Patient-centered care in Coronary Heart Disease: what do you want to measure? A systematic review of reviews on patient-reported outcome measures.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023
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  14. Examining Depression as a Risk Factor for Cardiovascular Disease in People with HIV: A Systematic Review.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2023
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256 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Robert M CarneyWashington University School of Medicine, 4320 Forest Park Avenue, Suite 301, St. Louis, Missouri 63108, USA.
Kenneth E FreedlandWashington University School of Medicine, 4320 Forest Park Avenue, Suite 301, St. Louis, Missouri 63108, USA.
Washington University in St. Louis · US

Funding

CARDIAC RISK MARKERS AND UNREMITTING DEPRESSION IN ACUTE CORONARY SYNDROMER01HL089336 · NHLBI · WASHINGTON UNIVERSITY · PI CARNEY, ROBERT M · 2009 to 2012
$2.9M
NHLBI NIH HHS R01 HL089336
6 · The paper itself

Abstract

Depression is a highly prevalent risk factor for incident coronary heart disease (CHD) and for cardiovascular morbidity and mortality in patients with established CHD. Several biological and behavioural mechanisms have been hypothesized to underlie the relationship between depression and CHD, but none has been shown to account for more than a small proportion of the risk. Only a few clinical trials have examined whether treating depression decreases the risk of cardiac events in patients with established CHD. None of these trials has shown that treatment results in improved cardiac outcomes, but the differences in depression outcomes between the intervention and control groups have been small and not clinically significant. Nevertheless, secondary analyses of these trials suggest that prognosis improves when depression improves. Concerted efforts to develop more potent interventions for depression, identification of high-risk subtypes of depression, and further research on the biobehavioural mechanisms linking depression to CHD are needed to pave the way for definitive clinical trials.

Indexed as

Coronary DiseaseDepressionHumansPrognosisRisk FactorsTreatment Outcome

Identifiers

PMID27853162
OpenAlexW2550749601

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.