ArticleNature communications2016
Formation of bacterial pilus-like nanofibres by designed minimalistic self-assembling peptides.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 34 citations in OpenAlex.
- Strong, tough, rapid-recovery, and fatigue-resistant hydrogels made of picot peptide fibres.Nature communications · 2023Article
- Stretchable and self-healable hydrogel artificial skin.National science review · 2022Article
- The Flp type IV pilus operon ofFrontiers in cellular and infection microbiology · 2022Article
- High-Throughput Peptide Derivatization toward Supramolecular Diversification in Microtiter Plates.ACS nano · 2021Article
- Electric field stimulates production of highly conductive microbial OmcZ nanowires.Nature chemical biology · 2020Article
- Ultrashort Peptide Self-Assembly: Front-Runners to Transport Drug and Gene Cargos.Frontiers in bioengineering and biotechnology · 2020Review
- Hierarchically oriented organization in supramolecular peptide crystals.Protein and peptide letters · 2019Article
- A cationic polymethacrylate-copolymer acts as an agonist for β-amyloid and an antagonist for amylin fibrillation.Chemical science · 2019Article
- Electrical Conductivity, Selective Adhesion, and Biocompatibility in Bacteria-Inspired Peptide-Metal Self-Supporting Nanocomposites.Advanced materials (Deerfield Beach, Fla.) · 2019Article
- Toward peptide-based bioelectronics: reductionist design of conductive pili mimetics.Bioelectronics in medicine · 2018Article
- Article
- Single-Handed Helical Polybissilsesquioxane Nanotubes and Mesoporous Nanofibers Prepared by an External Templating Approach Using Low-Molecular-Weight Gelators.Gels (Basel, Switzerland) · 2017Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Mimicking the multifunctional bacterial type IV pili (T4Ps) nanofibres provides an important avenue towards the development of new functional nanostructured biomaterials. Yet, the development of T4Ps-based applications is limited by the inability to form these nanofibres in vitro from their pilin monomers. Here, to overcome this limitation, we followed a reductionist approach and designed a self-assembling pilin-based 20-mer peptide, derived from the presumably bioelectronic pilin of Geobacter sulfurreducens. The designed 20-mer, which spans sequences from both the polymerization domain and the functionality region of the pilin, self-assembled into ordered nanofibres. Investigation of the 20-mer revealed that shorter sequences which correspond to the polymerization domain form a supramolecular β-sheet, contrary to their helical configuration in the native T4P core, due to alternative molecular recognition. In contrast, the sequence derived from the functionality region maintains a native-like, helical conformation. This study presents a new family of self-assembling peptides which form T4P-like nanostructures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.