Evidence map›Paper›PMID 27852975›Full record

ArticleAging2016

Jared K Woods, Tahereh Ziafazeli, Blanka Rogina

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Late-life shift in caloric intake affects fly metabolism and longevity.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  3. Epigenetic regulation of post-embryonic development.Current opinion in insect science · 2021
    Review
  4. Evolution, Chance, and Aging.Frontiers in genetics · 2021
    Review
  5. The Epigenetics of Aging in Invertebrates.International journal of molecular sciences · 2019
    Review
  6. Article
  7. Article
  8. The effects of reducedNutrition and healthy aging · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Jared K WoodsDepartment of Genetics & Genome Sciences, School of Medicine, University of Connecticut Health, Farmington, CT 06030, USA.
Tahereh ZiafazeliDepartment of Genetics & Genome Sciences, School of Medicine, University of Connecticut Health, Farmington, CT 06030, USA.
Blanka RoginaDepartment of Genetics & Genome Sciences, School of Medicine, University of Connecticut Health, Farmington, CT 06030, USA.
UConn Health · US

Funding

Molecular Genetics of Caloric Restriction in Aging FliesR01AG023088 · NIA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI ROGINA, BLANKA · 2004 to 2013
$3.2M
NIA NIH HHS R01 AG023088
6 · The paper itself

Abstract

Histone deacetylase (HDAC) 1 regulates chromatin compaction and gene expression by removing acetyl groups from lysine residues within histones. HDAC1 affects a variety of processes including proliferation, development, metabolism, and cancer. Reduction or inhibition of Rpd3, yeast and fly HDAC1 orthologue, extends longevity. However, the mechanism of

Indexed as

AgingAnimalsBlotting, WesternDown-RegulationDrosophila melanogasterDrosophila ProteinsFemaleForkhead Transcription FactorsGene ExpressionHistone Deacetylase 1InsulinLongevityMaleMutationSignal TransductionStarvationDrosophila ProteinsForkhead Transcription FactorsFOXO protein, DrosophilaHDAC1 protein, DrosophilaHistone Deacetylase 1InsulinagingDrosophila melanogasterInsulin/Insulin-like signalingRpd3

Identifiers

PMID27852975
PMCPMC5191884
OpenAlexW2551209151

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.