ArticlePlant physiology2017
A Cysteine-Rich Protein Kinase Associates with a Membrane Immune Complex and the Cysteine Residues Are Required for Cell Death.
Article in Plant physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.
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Who cites it
78 citing papers in PubMed, 167 citations in OpenAlex.
- Resistance to the oat leaf blotch pathogen (Pyrenophora avenae) is delimited to a region of chromosome 1D that harbors a candidate resistance kinase fusion protein.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Haplotype-resolved assemblies provide insights into genomic makeup of the oldest grapevine cultivar (Munage) in China.Horticulture research · 2026Article
- Genetic Diversity, Predictive Protein Structures, and Interaction Networks of Cysteine-Rich Receptor-Like Kinases inComputational and structural biotechnology journal · 2026Article
- A retrotransposon insertion upstream of Arabidopsis thaliana CRK8 receptor-like kinase modulates a trade-off between pathogen defense and salt tolerance.The Plant journal : for cell and molecular biology · 2025Article
- Cysteine-rich receptor-like secreted protein 1 promotes intercellular infection and enhances nodulation inHorticulture research · 2025Article
- Proteomic snapshot of pattern triggered immunity in the Arabidopsis leaf apoplast.The Plant journal : for cell and molecular biology · 2025Article
- Herbivory-induced green leaf volatiles increase plant performance through jasmonate-dependent plant-soil feedbacks.Nature plants · 2025Article
- Wheat tandem kinase RWT4 directly binds a fungal effector to activate defense.Nature genetics · 2025Article
- Evolutionary characteristics, expression patterns of wheat receptor-like kinases and functional analysis of TaCrRLK1L16.Stress biology · 2025Article
- More questions than answers: insights into potential cysteine-rich receptor-like kinases redox signalling in Arabidopsis.The Plant journal : for cell and molecular biology · 2025Review
- Spatiotemporal transcriptome and metabolome landscapes of cotton somatic embryos.Nature communications · 2025Article
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- Medicago truncatula genotype drives the plant nutritional strategy and its associated rhizosphere bacterial communities.The New phytologist · 2025Article
- Dual transcriptional characterization of spinach and Peronospora effusa during resistant and susceptible race-cultivar interactions.BMC genomics · 2024Article
- The CRK14 gene encoding a cysteine-rich receptor-like kinase is implicated in the regulation of global proliferative arrest in Arabidopsis thaliana.Genes to cells : devoted to molecular & cellular mechanisms · 2024Article
- An update on evolutionary, structural, and functional studies of receptor-like kinases in plants.Frontiers in plant science · 2024Review
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- The Expression ofPlants (Basel, Switzerland) · 2023Article
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- Comparative Transcriptome Profiling Unfolds a Complex Defense and Secondary Metabolite Networks ImpartingInternational journal of molecular sciences · 2023Article
18 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Membrane-localized proteins perceive and respond to biotic and abiotic stresses. We performed quantitative proteomics on plasma membrane-enriched samples from Arabidopsis (Arabidopsis thaliana) treated with bacterial flagellin. We identified multiple receptor-like protein kinases changing in abundance, including cysteine (Cys)-rich receptor-like kinases (CRKs) that are up-regulated upon the perception of flagellin. CRKs possess extracellular Cys-rich domains and constitute a gene family consisting of 46 members in Arabidopsis. The single transfer DNA insertion lines CRK28 and CRK29, two CRKs induced in response to flagellin perception, did not exhibit robust alterations in immune responses. In contrast, silencing of multiple bacterial flagellin-induced CRKs resulted in enhanced susceptibility to pathogenic Pseudomonas syringae, indicating functional redundancy in this large gene family. Enhanced expression of CRK28 in Arabidopsis increased disease resistance to P. syringae Expression of CRK28 in Nicotiana benthamiana induced cell death, which required intact extracellular Cys residues and a conserved kinase active site. CRK28-mediated cell death required the common receptor-like protein kinase coreceptor BAK1. CRK28 associated with BAK1 as well as the activated FLAGELLIN-SENSING2 (FLS2) immune receptor complex. CRK28 self-associated as well as associated with the closely related CRK29. These data support a model where Arabidopsis CRKs are synthesized upon pathogen perception, associate with the FLS2 complex, and coordinately act to enhance plant immune responses.
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