ArticleJournal of the Royal Society, Interface2016
Mechanical tuning of mammalian sperm behaviour by hyperactivation, rheology and substrate adhesion: a numerical exploration.
Article in Journal of the Royal Society, Interface, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Swimming by Spinning: Spinning-Top Type Rotations Regularize Sperm Swimming Into Persistently Progressive Paths in 3D.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Fluid flow reconstruction around a free-swimming sperm in 3D.bioRxiv : the preprint server for biology · 2024Article
- Construction of intelligent moving micro/nanomotors and their applications in biosensing and disease treatment.Theranostics · 2023Review
- "Motile-targeting" drug delivery platforms based on micro/nanorobots for tumor therapy.Frontiers in bioengineering and biotechnology · 2022Review
- Driving a Microswimmer with Wall-Induced Flow.Micromachines · 2021Article
- Rolling controls sperm navigation in response to the dynamic rheological properties of the environment.eLife · 2021Article
- Modelling Motility: The Mathematics of Spermatozoa.Frontiers in cell and developmental biology · 2021Review
- Response of monoflagellate pullers to a shearing flow: A simulation study of microswimmer guidance.Physical review. E · 2018Article
- Hydrodynamic Clustering of Human Sperm in Viscoelastic Fluids.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The great mammalian sperm race encounters numerous microenvironments to which sperm must adapt and a fundamental sperm response is the change in its waveform owing to both fluid rheology and capacitation, with the latter associated with a hyperactivated beat pattern. Hence, in this modelling study, we examine the effect of different flagellar waveforms for sperm behaviour near adhesive substrates, which are representative of epithelia in female tract sperm reservoirs and the zona pellucida (ZP), which surrounds the mammalian egg. On contact with an adhesive surface, virtual sperm rotate to become nearly tangential with the surface, as generally observed. Hyperactivation also induces many effects: sperm exert greater forces on the substrate and periodically tug way from adhesions under circumstances reflecting binding at sperm reservoirs, but with extensive fluid elasticity, as found in the cumulus surrounding the ZP, sperm instead continually push into the substrate. Furthermore, with weak adhesion, rheological media increase the duration hyperactivated sperm remain in the proximity of a substrate. More generally, such results predict that changes owing to both hyperactivation of the flagellar waveform and the rheology of the surrounding medium provide a means of tuning sperm behaviour near, or attached to, adhesive substrates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.