Evidence map›Paper›PMID 27852613›Full record

Trial reportThe American journal of clinical nutrition2017

Vitamin C-enriched gelatin supplementation before intermittent activity augments collagen synthesis.

Gregory Shaw, Ann Lee-Barthel, Megan Lr Ross, Bing Wang, Keith Baar

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of clinical nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04596553 (The Effects of Essential and Non-Essential Amino Acids on Post-Exercise Muscle Collagen Synthesis in Young Men), which is not on this map. Cited by 106 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed, 3 pooled it
10.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04596553 nacompletednot on this mapstarted 2021, after this paper: background citation

The Effects of Essential and Non-Essential Amino Acids on Post-Exercise Muscle Collagen Synthesis in Young Men: a Randomized Controlled Trial

TypeinterventionalSponsorUniversity of British ColumbiaRan2021 to 2022Enrolled17ConditionsSkeletal Muscle, Extracellular Matrix, Amino Acids Metabolism, ExerciseArmsEssential Amino Acid, Collagen Peptide, Maltodextrin Placebo
3 · Its place in the literature

Who cites it

106 citing papers in PubMed, 3 syntheses or guidelines pooled it, 200 citations in OpenAlex.

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46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

Gregory ShawSport Nutrition, Australian Institute of Sport, Canberra, Australia.
Ann Lee-BarthelNeurobiology, Physiology, and Behavior and.
Megan Lr RossSport Nutrition, Australian Institute of Sport, Canberra, Australia.
Bing WangCentre of Cardiovascular Research and Education in Therapeutics, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia; and.
Keith BaarNeurobiology, Physiology, and Behavior and kbaar@ucdavis.edu.
Australian Catholic University · AUInstitute of Neurobiology · BGMonash University · AUVA Northern California Health Care System · US

Funding

LAT1 and the development of anabolic resistanceR01AG045375 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BAAR, KEITH · 2014 to 2018
$1.7M
NIA NIH HHS R01 AG045375
6 · The paper itself

Abstract

backgroundMusculoskeletal injuries are the most common complaint in active populations. More than 50% of all injuries in sports can be classified as sprains, strains, ruptures, or breaks of musculoskeletal tissues. Nutritional and/or exercise interventions that increase collagen synthesis and strengthen these tissues could have an important effect on injury rates.

objectiveThis study was designed to determine whether gelatin supplementation could increase collagen synthesis.

designEight healthy male subjects completed a randomized, double-blinded, crossover-design study in which they consumed either 5 or 15 g of vitamin C-enriched gelatin or a placebo control. After the initial drink, blood was taken every 30 min to determine amino acid content in the blood. A larger blood sample was taken before and 1 h after consumption of gelatin for treatment of engineered ligaments. One hour after the initial supplement, the subjects completed 6 min of rope-skipping to stimulate collagen synthesis. This pattern of supplementation was repeated 3 times/d with ≥6 h between exercise bouts for 3 d. Blood was drawn before and 4, 24, 48, and 72 h after the first exercise bout for determination of amino-terminal propeptide of collagen I content.

resultsSupplementation with increasing amounts of gelatin increased circulating glycine, proline, hydroxyproline, and hydroxylysine, peaking 1 h after the supplement was given. Engineered ligaments treated for 6 d with serum from samples collected before or 1 h after subjects consumed a placebo or 5 or 15 g gelatin showed increased collagen content and improved mechanics. Subjects who took 15 g gelatin 1 h before exercise showed double the amino-terminal propeptide of collagen I in their blood, indicating increased collagen synthesis.

conclusionThese data suggest that adding gelatin to an intermittent exercise program improves collagen synthesis and could play a beneficial role in injury prevention and tissue repair. This trial was registered at the Australian New Zealand Clinical Trials Registry as ACTRN12616001092482.

Indexed as

Dietary SupplementsAdultAmino AcidsAscorbic AcidAthletic InjuriesBiomechanical PhenomenaCollagenCross-Over StudiesDouble-Blind MethodExerciseGelatinHumansLigamentsMalePeptide FragmentsProcollagenAmino AcidsAscorbic AcidCollagenGelatinPeptide FragmentsProcollagenprocollagen Type I N-terminal peptideboneexerciseinury preventionligamentreturn to playtendon

Identifiers

PMID27852613
PMCPMC5183725
OpenAlexW2556501772

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.