ArticleAge and ageing2017
Frailty and bone health in European men.
Article in Age and ageing, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- A systematic review of the relationship between body composition including muscle, fat, bone, and body water and frailty in Asian residents.Nagoya journal of medical science · 2025Pooled it
- Changes in frailty and incident risk of degenerative bone and joint diseases and their multimorbidity: a prospective cohort study.Frontiers in public health · 2026Article
- Association of serum neurofilament light chain and bone mineral density in adults.BMC musculoskeletal disorders · 2025Article
- Osteosarcopenia, osteoarthritis and frailty: a two-sample Mendelian randomization study.Aging clinical and experimental research · 2025Article
- Anemia as a mediator: bridging the frailty index and hip fractures in older Chinese populations.Frontiers in public health · 2025Article
- Exploring causality between bone mineral density and frailty: A bidirectional Mendelian randomization study.PloS one · 2024Article
- Frailty Prevention Care Management Program (FPCMP) on Frailty and Health Function in Community-Dwelling Older Adults: A Quasi-Experimental Trial Protocol.Healthcare (Basel, Switzerland) · 2023Article
- The Clinical Frailty Scale can be used retrospectively to assess the frailty of patients with hip fracture: a validation study.European geriatric medicine · 2022Article
- Article
- 30-day and 1-year mortality after skeletal fractures: a register study of 295,713 fractures at different locations.Acta orthopaedica · 2021Article
- The Predictability of Frailty Associated with Musculoskeletal Deficits: A Longitudinal Study.Calcified tissue international · 2021Article
- The contribution of musculoskeletal factors to physical frailty: a cross-sectional study.BMC musculoskeletal disorders · 2021Article
- Factors associated with physical, psychological and social frailty among community-dwelling older persons in Europe: a cross-sectional study of Urban Health Centres Europe (UHCE).BMC geriatrics · 2021Article
- Closing the Osteoporosis Care Gap.Current osteoporosis reports · 2021Review
- The association between a fracture risk tool and frailty: Geelong Osteoporosis Study.BMC geriatrics · 2020Article
- Allicin Reversed the Process of Frailty in Aging Male Fischer 344 Rats With Osteoporosis.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Frailty in Rheumatic Diseases.Frontiers in immunology · 2020Review
- Article
- Association between frailty and bone loss in patients undergoing maintenance hemodialysis.Journal of bone and mineral metabolism · 2019Article
- Abdominal obesity, sarcopenia, and osteoporosis are associated with frailty in men living with and without HIV.AIDS (London, England) · 2018Article
Corrections and comments
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Authors and funding
23 authors at 11 institutions in 7 countries.
Funding
Abstract
Background: frailty is associated with an increased risk of fragility fractures. Less is known, however, about the association between frailty and bone health. Methods: men aged 40-79 years were recruited from population registers in eight European centres for participation in the European Male Aging Study. Subjects completed a comprehensive assessment which included quantitative ultrasound (QUS) scan of the heel (Hologic-SAHARA) and in two centres, dual-energy bone densitometry (dual-energy x-ray absorptiometry, DXA). Frailty was defined based on an adaptation of Fried's phenotype criteria and a frailty index (FI) was constructed. The association between frailty and the QUS and DXA parameters was determined using linear regression, with adjustments for age, body mass index and centre. Results: in total, 3,231 subjects contributed data to the analysis. Using the Fried categorisation of frailty, pre-frail and frail men had significantly lower speed of sound (SOS), broadband ultrasound attenuation (BUA) and quantitative ultrasound index (QUI) compared to robust men (P< 0.05). Similar results were seen using the FI after categorisation into 'high', 'medium' and 'low' levels of frailty. Using the Fried categorisation, frail men had lower femoral neck bone mineral density (BMD) compared to robust men (P < 0.05), but not lower lumbar spine BMD. Using the FI categorisation, a 'high' level of frailty (FI > 0.35) was associated with lower lumbar spine BMD (P < 0.05) when compared to those with low (FI < 0.2), but not lower femoral neck BMD. When analysed as a continuous variable, higher FI was linked with lower SOS, BUA and QUI (P < 0.05). Conclusions: optimisation of bone health as well as prevention of falls should be considered as strategies to reduce fractures in frail older people.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.