ArticleJournal of the American Heart Association2016
Clinical Outcomes of Vasospastic Angina Patients Presenting With Acute Coronary Syndrome.
Article in Journal of the American Heart Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- Coronary Artery Spasm in Patients with Type 2 Diabetes Mellitus.Life (Basel, Switzerland) · 2026Review
- Diagnostic challenges in identifying myocardial infarction due to coronary vasospasm in pregnancy complicated by partial HELLP syndrome: a case report.European heart journal. Case reports · 2025Article
- Tailored treatment of specific diagnosis improves symptoms and quality of life in patients with myocardial Ischemia and Non-obstructive Coronary Arteries.Scientific reports · 2025Article
- RNF213 Variants, Vasospastic Angina, and Risk of Fatal Myocardial Infarction.JAMA cardiology · 2024Article
- Coronary Spasm Testing with Acetylcholine: A Powerful Tool for a Personalized Therapy of Coronary Vasomotor Disorders.Life (Basel, Switzerland) · 2024Review
- Coronary spasm and vasomotor dysfunction as a cause of MINOCA.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2024Review
- Clinical Outcomes of Calcium-Channel Blocker vs Beta-Blocker: From the Korean Acute Myocardial Infarction Registry.JACC. Asia · 2023Article
- Clinical Relevance of Ischemia with Nonobstructive Coronary Arteries According to Coronary Microvascular Dysfunction.Journal of the American Heart Association · 2022Article
- Vasospastic Angina: A Contemporary Review of its Pathophysiology, Diagnosis and Management.Heart international · 2022Review
- Current Evidence on Long-Term Prognostic Factors in Vasospastic Angina.Journal of clinical medicine · 2021Review
- Comparison of calcium-channel blockers for long-term clinical outcomes in patients with vasospastic angina.The Korean journal of internal medicine · 2021Article
- Non-atherosclerotic causes of acute coronary syndromes.Nature reviews. Cardiology · 2020Review
- Occurrence and mortality of vasospastic angina pectoris hospitalised patients in Finland: a population-based registry cohort study.BMJ open · 2019Article
- Usefulness of scoring system for diagnosis of vasospastic angina - Is spasm provocation test no longer needed?International journal of cardiology. Heart & vasculature · 2019Article
- Coronary vasospasm-induced polymorphic ventricular tachycardia: a case report and literature review.European heart journal. Case reports · 2018Article
- Long-term outcomes of a Caucasian cohort presenting with acute coronary syndrome and/or out-of-hospital cardiac arrest caused by coronary spasm.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2018Article
- Out-of-hospital cardiac arrest related to coronary arterial spasm in three elderly patients with no obstructive coronary artery disease.Journal of cardiology cases · 2017Article
- Unique Presentations and Etiologies of Myocardial Infarction in Women.Current treatment options in cardiovascular medicine · 2017Review
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCoronary vasospasm is an important pathogenesis of acute coronary syndrome (ACS). However, the clinical features and prognosis of vasospastic angina (VA) patients presenting with ACS (VAACS) are still unclear. We aimed to evaluate the clinical characteristics and long-term outcomes of VAACS patients without significant coronary artery stenosis. METHODS AND
resultsA total of 986 VA patients confirmed by ergonovine provocation test were analyzed. VAACS was defined as VA patients visiting the emergency room with documented electrocardiographic changes, significant arrhythmias, or elevated cardiac biomarkers. VA patients with elevated cardiac biomarkers were further considered to have myocardial infarction (MI; VAMI). During 4.4 years of median follow-up, we investigated major adverse cardiac events including cardiac death, MI, revascularization, and rehospitalization because of recurrent angina. The VAACS group consisted of 149 patients (15.1%), and VAMI occurred in 81 patients (8.2%). VAACS patients were younger and had a higher prevalence of diabetes mellitus, MI history, and higher levels of inflammatory markers compared with non-VAACS patients. In multivariable Cox regression analyses, VAACS patients were associated with an increased risk of major adverse cardiac events (hazard ratio, 1.65; 95% CI 1.14-2.37; P=0.007) and recurrent MI hazard ratio, 2.57; 95% CI, 1.35-4.87; P=0.004). In addition, VAMI patients had an increased risk of major adverse cardiac events (hazard ratio, 1.75; 95% CI, 1.11-2.76; P=0.016) and recurrent MI (hazard ratio, 2.43; 95% CI, 1.09-5.40; P=0.03).
conclusionVAACS patients showed worse clinical outcomes, driven mainly by recurrent MI. Therefore, intensive medical treatment might be required in VAACS patients.
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