Evidence map›Paper›PMID 27852294›Full record

ArticleWorld journal of surgical oncology2016

Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios predict chemotherapy outcomes and prognosis in patients with colorectal cancer and synchronous liver metastasis.

Yuchen Wu, Cong Li, Jiang Zhao, Li Yang, Fangqi Liu, Hongtu Zheng, Zhimin Wang, Ye Xu

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Article in World journal of surgical oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Yuchen WuDepartment of Oncology, Shanghai Medical College, Shanghai, 200032, China.
Cong LiDepartment of Oncology, Shanghai Medical College, Shanghai, 200032, China.
Jiang ZhaoDepartment of Oncology, Shanghai Medical College, Shanghai, 200032, China.
Li YangDepartment of Oncology, Shanghai Medical College, Shanghai, 200032, China.
Fangqi LiuDepartment of Oncology, Shanghai Medical College, Shanghai, 200032, China.
Hongtu ZhengDepartment of Oncology, Shanghai Medical College, Shanghai, 200032, China.
Zhimin WangDepartment of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center and Shanghai Industrial Technology Institute (SITI), Shanghai, 201203, China. wangzhm@chgc.sh.cn.
Ye XuDepartment of Oncology, Shanghai Medical College, Shanghai, 200032, China. xu_shirley021@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRecent evidence indicates that inflammatory parameters could be useful to predict metastasis from colorectal cancer. However, their roles in predicting chemotherapy response and prognosis in patients with synchronous colorectal liver metastasis (CLM) are unknown.

methodsThe clinical data and baseline laboratory parameters of 55 patients with synchronous CLM were retrospectively reviewed. All patients underwent palliative resection of the primary tumor and oxaliplatin-based chemotherapy. Two indices of systemic inflammation were reviewed-neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR)-preoperatively and before the second cycle of chemotherapy. Associations between prognostic variables and tumor response, progression, and survival were investigated.

resultsNLR < 4 and PLR < 150 were correlated with better disease control (p = 0.024 and 0.026, respectively). In univariate analysis, elevated NLR and PLR were significant prognostic factors for poor overall survival (OS) and progression-free survival (PFS). In multivariate analysis, PLR (p = 0.027), age (p = 0.018), resection of liver metastases (p = 0.017), and lactate dehydrogenase level (p = 0.011) were independent predictors of PFS, while resection of liver metastases was the only independent predictor of OS (p = 0.002). In addition, when patients were divided into groups according to changes in NLR and/or PLR, reduced NLR and PLR were associated with improved disease control (p = 0.038 and 0.025, respectively). Normalization of NLR also was associated with improved PFS.

conclusionsNLR and PLR are potentially useful clinical biomarkers to predict chemotherapy response in patients with synchronous CLM. PLR also may be useful to predict PFS in these patients.

Indexed as

Blood PlateletsLymphocytesNeutrophilsAdenocarcinomaAntineoplastic Combined Chemotherapy ProtocolsCapecitabineChemotherapy, AdjuvantColorectal NeoplasmsDeoxycytidineDisease-Free SurvivalFemaleFluorouracilHumansLeucovorinLiver NeoplasmsLymphocyte CountCapecitabineDeoxycytidineFluorouracilLeucovorinOrganoplatinum CompoundsOxaloacetatesChemotherapy responseNLRPLRPrognosisSynchronous colorectal liver metastasis

Identifiers

PMID27852294
PMCPMC5112720

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.