ArticleItalian journal of pediatrics2016
Serological screening for Celiac Disease in 382 pre-schoolers with Autism Spectrum Disorder.
Article in Italian journal of pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02708901 (Gut to Brain Interaction in Autism. Role of Probiotics on Clinical, Biochemical and Neurophysiological Parameters), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Gut to Brain Interaction in Autism. Role of Probiotics on Clinical, Biochemical and Neurophysiological Parameters
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Psychiatric Manifestations of Coeliac Disease, a Systematic Review and Meta-Analysis.Nutrients · 2020Pooled it
- Assessing the causal association between celiac disease and autism spectrum disorder: A two-sample Mendelian randomization approach.Autism research : official journal of the International Society for Autism Research · 2025Article
- Adverse food reactions and alterations in nutritional status in children with autism spectrum disorders: results of the NAFRA project.Italian journal of pediatrics · 2024Observational
- Celiac disease in autism spectrum disorder: data from an Italian child cohort.Italian journal of pediatrics · 2023Article
- Review
- Rotavirus vaccination is not associated with incident celiac disease or autoimmune thyroid disease in a national cohort of privately insured children.Scientific reports · 2022Article
- Dietary Patterns and Weight Status in Italian Preschoolers with Autism Spectrum Disorder and Typically Developing Children.Nutrients · 2021Article
- Prevalence and Clinical Features of Celiac Disease in a Cohort of Italian Children with Autism Spectrum Disorders.Nutrients · 2021Article
- Article
- Gluten and Autism Spectrum Disorder.Nutrients · 2021Review
- Brain Opioid Activity and Oxidative Injury: Different Molecular Scenarios Connecting Celiac Disease and Autistic Spectrum Disorder.Brain sciences · 2020Review
- Bridging the Gap Between Physical Health and Autism Spectrum Disorder.Neuropsychiatric disease and treatment · 2020Review
- Proband and Familial Autoimmune Diseases Are Associated With Proband Diagnosis of Autism Spectrum Disorders.Journal of the American Academy of Child and Adolescent Psychiatry · 2019Article
- HLA-class II haplotypes and Autism Spectrum Disorders.Scientific reports · 2018Article
- Immune Dysfunction and Autoimmunity as Pathological Mechanisms in Autism Spectrum Disorders.Frontiers in cellular neuroscience · 2018Review
- Behavioral Phenotype of ASD Preschoolers with Gastrointestinal Symptoms or Food Selectivity.Journal of autism and developmental disorders · 2017Article
- Advances in paediatrics in 2016: current practices and challenges in allergy, autoimmune diseases, cardiology, endocrinology, gastroenterology, infectious diseases, neonatology, nephrology, neurology, nutrition, pulmonology.Italian journal of pediatrics · 2017Review
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent investigations suggest a possible common genetic background between Autism Spectrum Disorders (ASD) and Celiac Disease (CD). However, studies regarding this association are scarce and often limited by the small sample sizes and/or large heterogeneity among ASD groups in terms of demographic and clinical features. The present study aims to investigate the overall CD prevalence (biopsy proven-CD patients plus screening detected tTG and EMA positive cases) in a large population of pre-schoolers with ASD referred to a tertiary care University Hospital.
methodsWe retrospectively collected data about 382 children (mean age: 46.97 ± 13.55 months; age-range: 18-72 months) consecutively diagnosed as ASD (according to the Diagnostic and Statistical Manual of Mental Disorders 4th edition criteria) over the period 2010-2013, and who performed a serological CD screening.
resultsThe overall CD prevalence was 2.62%, which is statistically significant higher to that reported in the Italian paediatric population (p = 0.0246). Half of these children had no symptoms or risk factors related to CD when they performed the serological screening.
conclusionsIf replicated, these data suggest the importance of regular screening for CD in young patients with ASD, and are of relevance for clinical and public health.
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