Evidence map›Paper›PMID 27852258›Full record

ArticleMalaria journal2016

Allele-specific antibodies to Plasmodium vivax merozoite surface protein-1: prevalence and inverse relationship to haemoglobin levels during infection.

Nuno Sepúlveda, Cristiane Guimarães Morais, Luiza Carvalho Mourão, Matheus França Freire, Cor Jesus F Fontes, Marcus Vinícius G Lacerda, Chris J Drakeley, Érika Martins Braga

Abstract read
In one paragraph

Article in Malaria journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nuno SepúlvedaDepartment of Immunology and Infection, London School of Hygiene & Tropical Medicine, London, UK.
Cristiane Guimarães MoraisDepartamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Luiza Carvalho MourãoDepartamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Matheus França FreireDepartamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Cor Jesus F FontesDepartamento de Clínica Médica, Hospital Universitário Júlio Müller, Universidade Federal de Mato Grosso, Cuiabá, Brazil.
Marcus Vinícius G LacerdaFundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil.
Chris J DrakeleyDepartment of Immunology and Infection, London School of Hygiene & Tropical Medicine, London, UK.
Érika Martins BragaDepartment of Immunology and Infection, London School of Hygiene & Tropical Medicine, London, UK. embraga@icb.ufmg.br.ORCID 0000-0001-5550-7157

Funding

Medical Research Council MR/M02623X/1Wellcome Trust 091924
6 · The paper itself

Abstract

backgroundAntigenic polymorphisms are considered as one of the main strategies employed by malaria parasites to escape from the host immune responses after infections. Merozoite surface protein-1 (MSP-1) of Plasmodium vivax, a promising vaccine candidate, is a highly polymorphic protein whose immune recognition is not well understood. METHODS AND

resultsThe IgG responses to conserved (MSP-1

conclusionsThese findings may have implications for vaccine development and represent an important step towards a better understanding of the polymorphic PvMSP-1 domain as potential targets of vaccine development. These data highlight the importance of extending the study of these polymorphic epitopes of PvMSP-1 to different epidemiological settings.

Indexed as

AllelesAdultAntibodies, ProtozoanEnzyme-Linked Immunosorbent AssayEpitopesFemaleHemoglobinsHumansImmunoglobulin GMalaria, VivaxMaleMerozoite Surface Protein 1Middle AgedPlasmodium vivaxSeroepidemiologic StudiesAntibodies, ProtozoanEpitopesHemoglobinsImmunoglobulin GMerozoite Surface Protein 1AnaemiaAntibodiesMSP-1Plasmodium vivaxPolymorphism

Identifiers

PMID27852258
PMCPMC5112628

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.