ArticleCell reports2016
CAPS1 RNA Editing Promotes Dense Core Vesicle Exocytosis.
Article in Cell reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Who cites it
25 citing papers in PubMed, 41 citations in OpenAlex.
- Neuron-specific deletion of ADAR1 induces brain malformation and early postnatal lethality.Journal of neuroinflammation · 2026Article
- Evolution of Engineered ADAR-Based RNA Editing Systems.International journal of molecular sciences · 2026Review
- RNA editing in disease: mechanisms and therapeutic potential.RNA (New York, N.Y.) · 2025Review
- RNA editing of AZIN1 coding sites is catalyzed by ADAR1 p150 after splicing.The Journal of biological chemistry · 2023Article
- Experimental evidence for the functional importance and adaptive advantage of A-to-I RNA editing in fungi.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- ADAR2 enzymes: efficient site-specific RNA editors with gene therapy aspirations.RNA (New York, N.Y.) · 2022Review
- RNA editing of ion channels and receptors in physiology and neurological disorders.Oxford open neuroscience · 2022Review
- Regulation and functional consequences of mGluRNA (New York, N.Y.) · 2021Article
- RNA editing-mediated regulation of calcium-dependent activator protein for secretion (CAPS1) localization and its impact on synaptic transmission.Journal of neurochemistry · 2021Article
- Review
- Systematic identification of A-to-I RNA editing in zebrafish development and adult organs.Nucleic acids research · 2021Article
- RNA editing at a limited number of sites is sufficient to prevent MDA5 activation in the mouse brain.PLoS genetics · 2021Article
- Adenosine-to-inosine RNA editing in the immune system: friend or foe?Cellular and molecular life sciences : CMLS · 2020Review
- Transcriptome profiling of porcine testis tissue reveals genes related to sperm hyperactive motility.BMC veterinary research · 2020Article
- CAPS1 Suppresses Tumorigenesis in Cholangiocarcinoma.Digestive diseases and sciences · 2020Article
- A comparative analysis of ADAR mutant mice reveals site-specific regulation of RNA editing.RNA (New York, N.Y.) · 2020Article
- Spatiotemporal mapping of RNA editing in the developing mouse brain using in situ sequencing reveals regional and cell-type-specific regulation.BMC biology · 2020Article
- Using mouse models to unlock the secrets of non-synonymous RNA editing.Methods (San Diego, Calif.) · 2019Review
- Dynamic inosinome profiles reveal novel patient stratification and gender-specific differences in glioblastoma.Genome biology · 2019Article
- Inosine induces context-dependent recoding and translational stalling.Nucleic acids research · 2019Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
Abstract
Calcium-dependent activator protein for secretion 1 (CAPS1) plays a distinct role in the priming step of dense core vesicle (DCV) exocytosis. CAPS1 pre-mRNA is known to undergo adenosine-to-inosine RNA editing in its coding region, which results in a glutamate-to-glycine conversion at a site in its C-terminal region. However, the physiological significance of CAPS1 RNA editing remains elusive. Here, we created mutant mice in which edited CAPS1 was solely expressed. These mice were lean due to increased energy expenditure caused by physical hyperactivity. Electrophysiological and biochemical analyses demonstrated that the exocytosis of DCVs was upregulated in the chromaffin cells and neurons of these mice. Furthermore, we showed that edited CAPS1 bound preferentially to the activated form of syntaxin-1A, a component of the exocytotic fusion complex. These findings suggest that RNA editing regulates DCV exocytosis in vivo, affecting physical activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.