Evidence map›Paper›PMID 27851959›Full record

ArticleCell reports2016

Identification of Serotonergic Neuronal Modules that Affect Aggressive Behavior.

Vera Niederkofler, Tedi E Asher, Benjamin W Okaty, Benjamin D Rood, Ankita Narayan, Lara S Hwa, Sheryl G Beck, Klaus A Miczek, Susan M Dymecki

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 121 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Vera NiederkoflerDepartment of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Tedi E AsherDepartment of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Benjamin W OkatyDepartment of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Benjamin D RoodDepartment of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Ankita NarayanDepartment of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Lara S HwaDepartment of Psychology, Tufts University, 530 Boston Avenue, Medford, MA 02155, USA.
Sheryl G BeckDepartments of Anesthesiology and Critical Care and Pharmacology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104; Department of Anesthesiology and Critical Care, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Klaus A MiczekDepartment of Psychology, Tufts University, 530 Boston Avenue, Medford, MA 02155, USA.
Susan M DymeckiDepartment of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. Electronic address: dymecki@genetics.med.harvard.edu.
Harvard University · USTufts University · USChildren's Hospital of Philadelphia · US

Funding

TUSM/T-NEMC CENTER FOR NEUROSCIENCE RESEARCH - Imaging CoreP30NS047243 · NINDS · TUFTS UNIVERSITY BOSTON · PI JACKSON, F ROB · 2003 to 2017
$10.0M
Behavioral Neurobiology of Aggression: Alcohol, GABA, and 5-HTR01AA013983 · NIAAA · TUFTS UNIVERSITY MEDFORD · PI WEERA, MARCUS MATTHIAS · 2003 to 2022
$8.0M
Developmental gene networks of 5HT neurons in addiction, aggression, and anxietyR01DA034022 · NIDA · HARVARD MEDICAL SCHOOL · PI DYMECKI, SUSAN M. · 2014 to 2018
$3.0M
Novel tools to study circuit function, development, and periods of vulnerabilityR21MH083613 · NIMH · HARVARD MEDICAL SCHOOL · PI DYMECKI, SUSAN M. · 2008 to 2009
$709k
Developmental Genetics of Serotonin Neuron Subtypes in Brain Reward CircuitsR21DA023643 · NIDA · HARVARD MEDICAL SCHOOL · PI DYMECKI, SUSAN M. · 2007 to 2010
$707k
Stress and alcohol drinking: early life dysregulation of neuropeptidesF31AA021622 · NIAAA · TUFTS UNIVERSITY MEDFORD · PI HWA, LARA STEPHANIE · 2013 to 2014
$84k
NIAAA NIH HHS F31 AA021622NIAAA NIH HHS R01 AA013983NIDA NIH HHS R01 DA034022NIDA NIH HHS R21 DA023643NIMH NIH HHS R21 MH083613NINDS NIH HHS P30 NS047243
6 · The paper itself

Abstract

Escalated aggression can have devastating societal consequences, yet underlying neurobiological mechanisms are poorly understood. Here, we show significantly increased inter-male mouse aggression when neurotransmission is constitutively blocked from either of two subsets of serotonergic, Pet1

Indexed as

AggressionAnimalsAxonsBehavior, AnimalBrainGene SilencingGenes, ReporterIntegrasesMaleMice, Inbred C57BLPhenotypeReceptors, Dopamine D2Reproducibility of ResultsSerotonergic NeuronsSynaptic TransmissionCre recombinaseIntegrasesReceptors, Dopamine D2aggressionaxonal projectionsdopamineintersectional geneticsneuronal subtypeserotonin

Identifiers

PMID27851959
PMCPMC5156533
OpenAlexW2550930670

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.