Evidence map›Paper›PMID 27851926›Full record

ArticleImmunity2016

Local Cellular and Cytokine Cues in the Spleen Regulate In Situ T Cell Receptor Affinity, Function, and Fate of CD8

Young-Jin Seo, Prithiviraj Jothikumar, Mehul S Suthar, Cheng Zhu, Arash Grakoui

Open access · bronzeAbstract read
In one paragraph

Article in Immunity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 32 citations in OpenAlex.

  1. CCR2Cellular & molecular immunology · 2025
    Article
  2. CD4Science advances · 2024
    Article
  3. Article
  4. Two-dimensional measurements of receptor-ligand interactions.Frontiers in molecular biosciences · 2023
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Relationship of 2D Affinity to T Cell Functional Outcomes.International journal of molecular sciences · 2020
    Review
  11. Viruses · 2020
    Article
  12. Article
  13. Review
  14. Single-molecule investigations of T-cell activation.Current opinion in biomedical engineering · 2019
    Article
  15. EndogenousInternational journal of molecular sciences · 2019
    Article
  16. Review
  17. Dynamics of Tissue-Specific CD8Journal of virology · 2018
    Article
  18. Article
  19. Environmental peer pressure: CD4Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2018
    Review
  20. The Journal of biological chemistry · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Young-Jin SeoDivision of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30329, USA; Yerkes National Primate Research Center, Emory Vaccine Center, Atlanta, GA 30329, USA.
Prithiviraj JothikumarWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Mehul S SutharYerkes National Primate Research Center, Emory Vaccine Center, Atlanta, GA 30329, USA; Department of Pediatrics and Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA 30329, USA.
Cheng ZhuWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA. Electronic address: cheng.zhu@bme.gatech.edu.
Arash GrakouiDivision of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30329, USA; Yerkes National Primate Research Center, Emory Vaccine Center, Atlanta, GA 30329, USA. Electronic address: arash.grakoui@emory.edu.
Emory University · USGeorgia Institute of Technology · US

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
YNPRC NHP CLINICAL MEDICINE RESIDENCY PROGRAM - SUPPLEMENTP51RR000165 · NCRR · EMORY UNIVERSITY · PI ALTMAN, JOHN DAVID · 1985 to 2011
$114.0M
Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Carlos del Rio · 2002 to 2026
$74.0M
West Nile Virus and host control of innate defensesU19AI083019 · NIAID · UNIVERSITY OF WASHINGTON · PI DIAMOND, MICHAEL S · 2009 to 2018
$22.5M
Mechanisms of hepatitis C virus persistenceR01AI070101 · NIAID · EMORY UNIVERSITY · PI GRAKOUI, ARASH · 2006 to 2016
$3.9M
T cell Immunity and the Outcome of Acute HCV InfectionR01AI126890 · NIAID · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI GRAKOUI, ARASH, WALKER, CHRISTOPHER M. · 2016 to 2020
$3.7M
T cell compartmentalization and antiviral responseR01AI124680 · NIAID · EMORY UNIVERSITY · PI GRAKOUI, ARASH, ZHU, CHENG · 2016 to 2020
$3.2M
Ligand Binding Kinetics and Cell Adhesion by Fc ReceptorR01AI038282 · NIAID · GEORGIA INSTITUTE OF TECHNOLOGY · PI ZHU, CHENG · 2001 to 2005
$1.9M
Statistical Modeling of Receptor/Ligand Binding Kinetics on the T cell SurfaceR01GM096187 · NIGMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI WU, CHIEN-FU JEFF · 2010 to 2012
$879k
Host and viral determinants of hepatitis C virus macaque infectionR21AI118337 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI EVANS, MATTHEW J, GRAKOUI, ARASH · 2015 to 2016
$499k
Regulation of T cell immunity by the cytosolic RIG-I like receptorsR56AI110516 · NIAID · EMORY UNIVERSITY · PI SUTHAR, MEHUL SHAMAL · 2014 to 2014
$443k
Kinetic analysis of ligand binding by TCR and CD8R56AI038282 · NIAID · GEORGIA INSTITUTE OF TECHNOLOGY · PI ZHU, CHENG · 2012 to 2012
$389k
NCRR NIH HHS P51 RR000165NIAID NIH HHS HHSN272201300006CNIAID NIH HHS P30 AI050409NIAID NIH HHS R01 AI038282NIAID NIH HHS R01 AI070101NIAID NIH HHS R01 AI124680NIAID NIH HHS R01 AI126890NIAID NIH HHS R21 AI118337NIAID NIH HHS R29 AI038282NIAID NIH HHS R56 AI038282NIAID NIH HHS R56 AI110516NIAID NIH HHS U19 AI083019NIGMS NIH HHS R01 GM096187NIH HHS P51 OD011132
6 · The paper itself

Abstract

T cells rapidly undergo contraction upon viral clearance, but how T cell function and fate are determined during this phase is unclear. During the contraction phase of an acute infection with lymphocytic choriomeningitis virus, we found that virus-specific CD8

Indexed as

AnimalsCD8-Positive T-LymphocytesCell DifferentiationCell SeparationCytokinesDisease Models, AnimalFlow CytometryGene Expression ProfilingImmunologic MemoryLymphocytic ChoriomeningitisMaleMiceMice, Inbred C57BLMice, TransgenicReceptors, Antigen, T-CellSpleenCytokinesReceptors, Antigen, T-Cellanti-viral CD8(+) T cell responsesimmune contractionLCMVpeptide MHC interactionred pulpsplenic compartmentsT cell memoryT cell receptorwhite pulp

Identifiers

PMID27851926
PMCPMC5131716
OpenAlexW2550607651

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.