Evidence map›Paper›PMID 27851908›Full record

ArticlePharmacology, biochemistry, and behavior

N-phenylpropyl-N'-substituted piperazines occupy sigma receptors and alter methamphetamine-induced hyperactivity in mice.

Dennis K Miller, Eric S Park, Susan Z Lever, John R Lever

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacology, biochemistry, and behavior. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Dennis K MillerDepartment of Psychological Sciences, University of Missouri, Columbia, MO 65211, USA; Center for Translational Neuroscience, College of Medicine, University of Missouri, Columbia, MO 65211, USA. Electronic address: millerden@missouri.edu.
Eric S ParkCenter for Translational Neuroscience, College of Medicine, University of Missouri, Columbia, MO 65211, USA.
Susan Z LeverDepartment of Chemistry, University of Missouri, Columbia, MO 65211, USA; Research Reactor Center, University of Missouri, Columbia, MO 65211, USA.
John R LeverResearch Service, Harry S. Truman Memorial Veterans' Hospital, Columbia, MO 65201, USA; Department of Radiology, University of Missouri, Columbia, MO 65211, USA.
University of Missouri · USHarry S. Truman Memorial Veterans' Hospital · US

Funding

Development of Anti-Cocaine MedicationsRC1DA028477 · NIDA · UNIVERSITY OF MISSOURI-COLUMBIA · PI LEVER, JOHN RILEY · 2009 to 2010
$679k
NIDA NIH HHS RC1 DA028477
6 · The paper itself

Abstract

This study examined the effect of the N-phenylpropyl-N'-substituted piperazine ligands SA4503 (3.4-dimethoxyphenethyl), YZ-067 (4-methoxyphenethyl), YZ-185 (3-methoxyphenethyl) and Nahas-3h (4-methoxybenzyl) on methamphetamine-induced hyperactivity in mice. In a previous study in rats, SA4503 increased methamphetamine-induced hyperactivity at a lower ligand dose and enhanced it at a higher dose. The other ligands have not been investigated in this assay. Presently, mice were administered sigma ligands, and specific [

Indexed as

AnimalsCocaineHyperkinesisMaleMethamphetamineMicePiperazinesReceptors, sigmaStructure-Activity RelationshipCocaineMethamphetaminePiperazinesReceptors, sigmaRTI 121SA 4503BehaviorDopamine transporterLocomotor activityMethamphetamineMouseReceptor occupancySigma receptor

Identifiers

PMID27851908
PMCPMC5244969
OpenAlexW2550397581

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.