Evidence map›Paper›PMID 27851889›Full record

ArticleJournal of immunological methods2017

A novel method for assaying human regulatory T cell direct suppression of B cell effector function.

Elizabeth Weingartner, Jean-Paul Courneya, Achsah Keegan, Amit Golding

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunological methods, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Elizabeth WeingartnerBaltimore VA Medical Center, 10 N Greene St, Baltimore, MD 21201, United States; Department of Medicine, University of Maryland School of Medicine, Division of Rheumatology and Clinical Immunology, 10 S. Pine Street/MSTF Room 8-34, Baltimore, MD 21201, United States. Electronic address: eweingartner@umaryland.edu.
Jean-Paul CourneyaBaltimore VA Medical Center, 10 N Greene St, Baltimore, MD 21201, United States; Department of Medicine, University of Maryland School of Medicine, Division of Rheumatology and Clinical Immunology, 10 S. Pine Street/MSTF Room 8-34, Baltimore, MD 21201, United States. Electronic address: jpcourneya@hshsl.umaryland.edu.
Achsah KeeganBaltimore VA Medical Center, 10 N Greene St, Baltimore, MD 21201, United States; Department of Medicine, University of Maryland School of Medicine, Division of Rheumatology and Clinical Immunology, 10 S. Pine Street/MSTF Room 8-34, Baltimore, MD 21201, United States. Electronic address: akeegan@som.umaryland.edu.
Amit GoldingBaltimore VA Medical Center, 10 N Greene St, Baltimore, MD 21201, United States; Department of Medicine, University of Maryland School of Medicine, Division of Rheumatology and Clinical Immunology, 10 S. Pine Street/MSTF Room 8-34, Baltimore, MD 21201, United States. Electronic address: agolding@medicine.umaryland.edu.
University of Maryland, Baltimore · US

Funding

Investigation of Regulatory T Cells in Veterans with Rheumatologic DiseaseIK2CX000649 · VA · BALTIMORE VA MEDICAL CENTER · PI GOLDING, AMIT · 2012 to 2015
–
CSRD VA IK2 CX000649
6 · The paper itself

Abstract

We have established a highly reproducible and reliable protocol for testing human regulatory T cell function in suppressing IgM production from an immature human B cell line. The autoreactive Ramos B cell line provides a stable reporter of B cell effector function that can be tested by a straight-forward IgM ELISA. Tregs from healthy volunteers display a range of ability for suppressing baseline IgM production in a contact- and death-independent manner. Having established the normal range for human Treg direct suppression of B cell effector function, it will now be possible to efficiently test Tregs from various autoimmune conditions in which B cell hyperactivity and secretion of auto-antibodies are a hallmark of disease.

Indexed as

Immunologic TechniquesAutoimmunityB-Lymphocyte SubsetsCell LineHumansImmunoglobulin MT-Lymphocytes, RegulatoryImmunoglobulin MAntibodyAutoimmunityB cellHumanSuppression assayTreg

Identifiers

PMID27851889
PMCPMC7282517
OpenAlexW2554052515

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.