ArticleMagnetic resonance in medicine2017
Dual-volume excitation and parallel reconstruction for J-difference-edited MR spectroscopy.
Article in Magnetic resonance in medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Proton Magnetic Resonance Spectroscopy for Pediatric Neuroimaging: Key Concepts for Practice.Seminars in ultrasound, CT, and MR · 2025Review
- Human brain functional MRS reveals interplay of metabolites implicated in neurotransmission and neuroenergetics.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Estimation and removal of spurious echo artifacts in single-voxel MRS using sensitivity encoding.Magnetic resonance in medicine · 2021Article
- In Vivo Brain GSH: MRS Methods and Clinical Applications.Antioxidants (Basel, Switzerland) · 2021Review
- Metabolic underpinnings of activated and deactivated cortical areas in human brain.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Accelerated J-resolvedMagnetic resonance in medicine · 2021Article
- Article
- Hadamard editing of glutathione and macromolecule-suppressed GABA.NMR in biomedicine · 2018Article
- Big GABA: Edited MR spectroscopy at 24 research sites.NeuroImage · 2017Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeTo develop J-difference editing with parallel reconstruction in accelerated multivoxel (PRIAM) for simultaneous measurement in two separate brain regions of γ-aminobutyric acid (GABA) or glutathione.
methodsPRIAM separates signals from two simultaneously excited voxels using receiver-coil sensitivity profiles. PRIAM was implemented into Mescher-Garwood (MEGA) edited experiments at 3 Tesla (T), and validated by acquiring dual-voxel MEGA-PRIAM (and compared with conventional single-voxel MEGA-PRESS) spectra from a GABA/glutathione phantom, and 11 healthy participants.
resultsMEGA-PRIAM effectively separated phantom spectra with ∼3-4% between-voxel contamination. GABA and glutathione measurements agreed well with those obtained using single-voxel MEGA-PRESS (mean difference was below 2% in GABA levels, and below 7% in glutathione levels). In vivo, GABA- and glutathione-edited spectra were successfully reconstructed with a mean in vivo g-factor of 1.025 (typical voxel-center separation: 7-8 cm). MEGA-PRIAM experiments showed higher signal-to-noise ratio than sequential single-voxel experiments of the same total duration (mean improvement 1.38 ± 0.24).
conclusionsSimultaneous acquisition of J-difference-edited GABA or glutathione spectra from two voxels is feasible at 3 T. MEGA-PRIAM increases data acquisition rates compared with MEGA-PRESS by a factor of 2. Magn Reson Med, 2016. © 2016 International Society for Magnetic Resonance in Medicine.
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