ArticleThe American journal of surgical pathology2017
Reduced H3K27me3 Expression Is Common in Nodular Melanomas of Childhood Associated With Congenital Melanocytic Nevi But Not in Proliferative Nodules.
Article in The American journal of surgical pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 48 citations in OpenAlex.
- Mitotic Proliferative Nodule Within a Giant Congenital Nevus: One Case Report and Updated Review.Dermatopathology (Basel, Switzerland) · 2026Review
- Gene fusions in melanocytic lesions: an updated comprehensive review.Journal of pathology and translational medicine · 2026Article
- Advances in Epigenomic Sequencing and Their Applications in Cancer Diagnostics.Precision chemistry · 2025Review
- Congenital melanocytic naevi initiated by BRAF fusion oncogene with firmness, pruritus and desmoplastic stroma.The British journal of dermatology · 2025Article
- Congenital melanocytic neoplasms: clinical, histopathological and recent molecular developments.Virchows Archiv : an international journal of pathology · 2025Review
- Pseudomalignancies in Children: Histological Clues, and Pitfalls to Be Avoided.Dermatopathology (Basel, Switzerland) · 2021Review
- Cutaneous Melanomas Arising during Childhood: An Overview of the Main Entities.Dermatopathology (Basel, Switzerland) · 2021Review
- Utility of histone H3K27me3 and H4K20me as diagnostic indicators of melanoma.Melanoma research · 2020Article
- Histone H3K27 dimethyl loss is highly specific for malignant peripheral nerve sheath tumor and distinguishes true PRC2 loss from isolated H3K27 trimethyl loss.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2019Article
- An update on molecular alterations in melanocytic tumors with emphasis on Spitzoid lesions.Annals of translational medicine · 2018Review
- Unclassified sclerosing malignant melanomas with AKAP9-BRAF gene fusion: a report of two cases and review of BRAF fusions in melanocytic tumors.Virchows Archiv : an international journal of pathology · 2018Review
- Reduced H3K27me3 expression in radiation-associated angiosarcoma of the breast.Virchows Archiv : an international journal of pathology · 2018Article
- Loss of H3K27 trimethylation is not suitable for distinguishing malignant peripheral nerve sheath tumor from melanoma: a study of 387 cases including mimicking lesions.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2017Article
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6 authors at 4 institutions in 2 countries.
Funding
Abstract
The formation of a nodule within a congenital melanocytic nevus (CMN) raises concerns about possible melanoma. Most new nodular growths that develop during childhood, however, are benign proliferative nodules (PN); melanoma is very rare. The distinction of melanoma from PN can at times be difficult clinically and histopathologically, requiring ancillary molecular tests for diagnosis. Although the application of molecular methods has revealed new insights into the mutational and genomic landscape of childhood melanomas, little is known about epigenetic events that may drive the growth of a melanoma or PN in a CMN. In this study we compared the expression of H3K27me3, a key regulator in chromatin remodelling-controlled transcription, in PNs and pediatric nodular melanomas arising within medium-sized to large CMN by immunohistochemistry. Significant loss of H3K27me3 expression was seen in 4 of 5 melanomas, but not in any of the 20 PNs. This observation suggests that epigenetic events likely play a role in the pathogenesis of melanoma developing in the dermis or subcutis of CMN. Furthermore, assessing for H3K27me3 expression by immunohistochemistry may be diagnostically useful for problematic cases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.